年龄、性别及季节与西安市0～12岁儿童维生素D状态的相关性研究  

The Correlation of Vitamin D Status of Children Aged 0 to 12 with Age,Gender and Season in Xi'an City

作　　者：王伟[1] 杨丽芳[1] 董莉[2] 张瑛[1] 张欢[1] 俱西驰[3] 陆亚红[1] Wang Wei;Yang Lifang;Dong Li;Zhang Ying;Zhang Huan;Ju Xichi;Lu Yahong(Department of Child Health Care,Shaanxi Provincial People's Hospital,Xi'an 710068,China;Diagnostic Center of Nuclear Medicine,Shaanxi Provincial People's Hospital,Xi'an 710068,China;Department of Neurology,The First Affiliated hospital of Xi'an Jiaotong University,Xi'an 710061,China)

机构地区：[1]陕西省人民医院儿童保健科,西安710068 [2]陕西省人民医院核医学诊断中心,西安710068 [3]西安交通大学第一附属医院神经内科,西安710061

出　　处：《成都医学院学报》2018年第1期32-36,共5页Journal of Chengdu Medical College

基　　金：国家自然科学青年基金资助项目(No:81201426);陕西省自然科学基础研究计划项目(No:2016JM8006)

摘　　要：目的分析年龄、性别及季节对西安市0~12岁儿童维生素D状态的影响,为本地区防治儿童维生素D缺乏提供科学依据。方法采用化学发光法检测1 333例0~12岁西安市健康儿童血清25-(OH)D水平,并进行统计学分析。结果 0~12岁儿童血清25-(OH)D总体水平为(31.69±17.07)ng/mL。1 333例儿童中,血清25-(OH)D充足618例(46.36%)、缺乏444例(33.31%)、不足组256例(19.20%)。不同年龄组血清25-(OH)D水平比较差异有统计学意义(P<0.05)。婴儿组血清25-(OH)D水平为(38.17±18.40)ng/mL,学龄组为(24.02±13.21)ng/mL,随着年龄增长,血清25-(OH)D水平降低。学龄组男童血清25-(OH)D水平低于女童(P<0.05)。春、夏季血清25-(OH)D水平均高于冬季(P<0.05)。冬季维生素D缺乏及不足率均高于其他3组(P<0.05)。结论西安市3~12岁儿童普遍存在维生素D缺乏或不足,应加强该年龄段儿童户外活动;必要时给予维生素D制剂干预。Objective To analyze the impact of age,gender and season on the vitamin D status of children aged 0 to 12 in Xi'an city and provide a theoretical basis for the prevention and treatment of children with vitamin D deficiency.Methods The serum 25-(OH)D levels of 1333 cases of healthy children aged 0 to 12 from Xi'an city were detected by the chemiluminescence method and analyzed statistically.Results The average serum 25-(OH)D level of those children was(31.69±17.07)ng/mL.There were 618 cases(46.36%)with vitamin D sufficiency,444 cases(33.31%)with vitamin D insufficiency,256 cases(19.20%)with vitamin D deficiency among those children.The serum 25-(OH)D levels were significantly different between different age groups(P<0.05).The serum 25-(OH)D levels were(38.17±18.40)ng/mL in the infant group and(24.02±13.21)ng/mL in the school-age group,and they decreased with the growth of age.The serum 25-(OH)D levels of boys were significantly lower than those of girls in the school-age group(P<0.05).The serum 25-(OH)D levels were significantly higher in Spring and Summer than in Winter(P<0.05).The percentages of vitamin D deficiency or insufficiency were significantly higher in winter than in the other three seasons(P<0.05).Conclusion A high incidence of vitamin D deficiency or insufficiency is found in children aged 3 to 12 in Xi'an city,so outdoor activities should be strengthened for them and vitamin D preparations should be given to them if necessary.

关 键 词：儿童 维生素D 25-羟维生素D 

分 类 号：R723.2[医药卫生—儿科]