雷公藤多苷联合泼尼松对SLE患者CD4^+ CD25^+ T细胞的影响及其疗效  

Influence of tripterygium glycosides combined with prednisone on CD4^+ CD25^+ T cells in patients with systemic lupus erythematosus and its curative effect

作　　者：李广科[1] 李娟 袁耀[1] 赵亚伟[1] 王格[1] LI Guangke;LI Juan;YUAN Yao;ZHAO Yawei;WANG Ge(Department of Immunology,Luohe Municipal Central Hospital/First Affiliated Hospital of Luohe Medical College,Luohe,Henan 462000,China)

机构地区：[1]河南省漯河市中心医院/漯河医学高等专科学校第一附属医院风湿免疫科,462000

出　　处：《检验医学与临床》2018年第6期798-801,共4页Laboratory Medicine and Clinic

摘　　要：目的探讨雷公藤多苷联合泼尼松对系统性红斑狼疮(SLE)患者CD4^+ CD25^+ T细胞的影响及其疗效。方法选取该院2014年12月至2016年10月接诊的100例SLE患者作为研究对象,按随机数字表法分为两组,每组50例。观察组采用雷公藤多苷联合泼尼松进行治疗,对照组仅采用泼尼松进行治疗,分析两组患者使用不用的药物方案对CD4^+ CD25^+ T细胞的影响,对比两组患者治疗前后的SLE活动指数(SLE-DAI)评分、临床疗效及治疗后的不良反应。结果两组患者治疗前的CD4^+ CD25^+ T细胞水平比较,差异无统计学意义(P>0.05),两组患者治疗后CD4^+ CD25^+ T细胞水平明显升高,并且观察组明显高于对照组,差异有统计学意义(P<0.05);两组患者治疗前的SLE-DAI评分比较,差异无统计学意义(P>0.05),观察组和对照组治疗后评分明显降低,并且观察组患者的SLE-DAI评分显著低于对照组,差异有统计学意义(P<0.05);观察组患者治疗后的总有效率为92%,高于对照组的74%,差异有统计学意义(P<0.05);两组患者治疗后在肝功能异常、恶心呕吐、肺炎、上呼吸道感染、白细胞计数下降方面比较,差异无统计学意义(P>0.05),观察组患者治疗后出现月经紊乱9例,对照组出现2例,观察组发生率明显高于对照组,差异有统计学意义(P<0.05)。结论雷公藤多苷联合泼尼松治疗SLE,能够提高CD4^+ CD25^+ T细胞水平,可保护、恢复SLE患者的器官损伤,治疗后出现少数不良反应,并且对月经周期有一定的影响,但均在可控范围内,值得临床推广应用。Objective To investigate the influence of tripterygium glycosides combined with prednisone on the CD4+CD25+T cells in the patients with systemic lupus erythematosus(SLE)and its curative effect.Methods One hundred cases of SLE in this hospital from December 2014 to October 2016 were seleted as the research subjects and randomly divided into the two groups,50 cases in each group.The observation group adopted the therapy of tripterygium glycosides combined with prednisone,while the control group only adopted prednisone treatment.The influence of different medication schemes on CD4+CD25+T cells was analyzed in the two groups,and the SLE activity index(SLE-DAI)score,clinical effect and adverse reactions after treatment were compared between the groups.Results The CD4+CD25+T cell level before treatment had no statistical difference between the two groups(P>0.05),the level of CD4+CD25+T cells after treatment in the two groups was significantly increased compared with that before treatment,moreover the observation group was significantly higher than the control group,the difference was statistically significant(P<0.05);the SLE-DAI score before treatment had no statistical difference between the two groups(P>0.05),the score after treatment in the observation group and control group was significantly decreased,moreover the score in the observation group was significantly lower that that in the control group,the difference was statistically significant(P<0.05);the total effective rate after treatment in the observation group was 92%,which in the control group was 74%,the effective rate in the observation group was obviously higher than that in the control group,the difference was statistically significant(P<0.05);in the aspects of liver function abnormality,nausea and vomiting,pneumonia,upper respiratory tract infection and white blood cell count after treatment had no statistical difference between the two groups(P>0.05);nine cases in the observation group appeared menstrual disorder after treatment and there were 2 cases

关 键 词：雷公藤多苷 泼尼松 系统性红斑狼疮 CD4+CD25+T细胞 

分 类 号：R446.62[医药卫生—诊断学]