拉贝洛尔与硝苯地平治疗重度子痫前期对血压及孕产妇和围产儿结局的影响  

Effects of labetalol and nifedipine in the treatment of severe preeclampsia on blood pressure and perinatal outcome of pregnant women

作　　者：史丹丹[1] 王勇[1] 郭君君[1] 王娜[1] 白玉来 王学珍 史亚玲 SHI Danda;WANG Yong;GUO Junjun(Department of Obstetrics,Central Hospital of Cangzhou City,Hebei,Cangzhou 061000,China)

机构地区：[1]河北省沧州市中心医院产科,061000 [2]河产省黄骅市中医医院心内科 [3]河北省任丘市妇幼保健院妇产科

出　　处：《河北医药》2018年第5期673-676,680,共5页Hebei Medical Journal

基　　金：河北省科学技术研究与发展支撑计划项目(编号:20171305)

摘　　要：目的观察拉贝洛尔与硝苯地平治疗重度子痫前期对血压及孕产妇围产儿结局的影响。方法 147例重度子痫前期孕妇随机分为硝苯地平组(71例)与拉贝洛尔组(76例),分别予以相应的药物治疗。观察2组患者血压控制、孕产妇与围产儿结局变化。结果硝苯地平组总有效率为94.37%,拉贝洛尔组总有效率为90.79%,2组总有效率比较差异无统计学意义(P>0.05)。治疗后1 h、24 h 2组患者收缩压及舒张压均较治疗前显著下降,差异有统计学意义(P<0.05),但2组同一时间组间比较血压水平差异无统计学意义(P>0.05)。与治疗前相比,治疗后2组患者24 h尿蛋白定量均显著降低,24 h尿量增加(P<0.05),但组间比较差异无统计学意义(P>0.05)。2组妊娠并发症发生率、早产、剖宫产、产后出血等发生率及新生儿窒息、低体重儿等发生率比较差异无统计学意义(P>0.05)。结论硝苯地平及拉贝洛尔治疗重症子痫前期均安全有效地改善母婴结局,保障母婴安全。Objective To observe the effects of labetalol and nifedipine in the treatment of severe preeclampsia on blood pressure and perinatal outcome of pregnant women.Methods A total of 147 pregnant women with severe preeclampsia were randomly divided into nifedipine group(n=71)and labetalol group(n=76).The patients were treated with the corresponding drugs.The blood pressure control,maternal and perinatal outcome were observed and compared between two groups.Results The total effective rate in nifedipine group and in labetalol group was 94.37%and 90.79%,respectively,there was no significant difference between two groups(P>0.05),however,the systolic pressure and diastolic pressure at 1h,24h after treatment were significantly decreased in both groups(P<0.05),but there were no significant differences in blood levels at the same time point between two groups(P>0.05).As compared with those before treatment,the urinary protein was significantly decreased after treatment in both groups,however,the 24h urine volume was significantly increased(P<0.05),but there was no significant difference between two groups(P>0.05).Moreover there were no significant differences in the incidence rates of preoperative complications,preterm birth,cesarean section,postpartum hemorrhage as well as neonatal asphyxia and low body mass between two groups(P>0.05).Conclusion Both nifedipine and labetalol in treatment of severe preeclampsia can improve safely and effectively the maternal-infant outcomes to protect the maternal-infant safe.

关 键 词：重度子痫前期 血压 拉贝洛尔 硝苯地平 

分 类 号：R714.245[医药卫生—妇产科学]