离子色谱法测定葡维氨糖胶囊中盐酸氨基葡萄糖和维生素C的含量  

Determination of glucosamine hydrochloride and vitamin C of Puweiantang Capsules by ion chromatography

作　　者：丰航[1] 陈德妙 李荣 单敏 FENG Hang;CHEN Demiao;LI Rong;SHAN Min(Department of Pharmacy,Shaanxi Provincial People′s Hospital,Xi′an 710068,China;Xi′an Institute for Food and Drug Control,Xi′an 710054,China)

机构地区：[1]陕西省人民医院药学部,西安710068 [2]西安市食品药品检验所,西安710054

出　　处：《西北药学杂志》2018年第2期185-188,共4页Northwest Pharmaceutical Journal

摘　　要：目的建立葡维氨糖胶囊中盐酸氨基葡萄糖和维生素C含量的检测方法。方法以10mmol·L-1氢氧化钾溶液为淋洗液,经Ion Pac AS-19 250mm×4mm柱(带Ion Pac AS-19 50mm×4mm保护柱)分离,电导检测器检测。结果盐酸氨基葡萄糖与维生素C质量浓度在50~500μg·mL-1范围内均呈良好的线性关系,回收率分别为98.91%和99.46%,RSD值分别为0.62%和0.88%。结论该方法操作简便、灵敏度高、专属性强、准确度和重复性良好,可为该产品的质量控制提供参考。Objective To establish an ion chromatography method for the determination of glucosamine hydrochloride and vitamin C of Puweiantang Capsules.Methods The assay was performed on an Ion Pac AS-19250mm×4mm column(with Ion Pac AS-1950mm×4mm protective column)using10mmol·L-1KOH and detected by conductivity detector.Results The linear ranges of glucosamine hydrochloride and vitamin C were50-500μg·mL-1.The average recoveries were98.91%and99.46%,RSD were0.62%and0.88%,respectively.Conclusion The method is simple,sensitive and selective,has good accuracy and reproducibility,and can provide reference for the quality control of the product.

关 键 词：盐酸氨基葡萄糖 维生素C 葡维氨糖胶囊 离子色谱法 

分 类 号：R927.2[医药卫生—药学]