精神科住院患者146例药品不良反应报告分析  

Analysis of 146 adverse drug reaction reports of psychiatric hospital inpatients

作　　者：杨燕 李丽[1] 汪蜜[1] 肖林[1] 何文富[1] 谢亚菲 YANG Yan;LI Li;WANG Mi;XIAO Lin;HE Wenfu;XIE Yafei(The Chengdu Fourth People′s Hospital,Chengdu Mental Health Center,Chengdu 610031,China)

机构地区：[1]成都市第四人民医院,成都市精神卫生中心,成都610031

出　　处：《西北药学杂志》2018年第2期271-273,共3页Northwest Pharmaceutical Journal

摘　　要：目的分析某三甲精神专科医院住院患者药品不良反应(ADR)的发生情况,为精神科临床合理用药提供参考。方法回顾性分析该院2016年上报至国家药品不良反应监测系统的146例ADR报告。结果 146例报告中,男性(55.85%)多于女性(43.15%)。30~49岁患者(36.99%)占比例最大。抗精神病药物引起的ADR最多(74.66%),其中发生频率最高的是氟哌啶醇(17.81%)、利培酮口腔崩解片(13.01%)和氯氮平(12.33%)。ADR主要累及器官或系统多为神经系统(55.48%),其中锥体外系反应最多(30.14%)。ADR对原患疾病影响多不明显(91.78%)。结论精神科住院患者发生ADR多见,临床应加强监测,保障用药安全。Objective To analyze the adverse drug reaction(ADR)of psychiatric hospital inpatients in a tertiary specialist hospital,and to provide a reference for clinical rational use of psychotropic drugs.Methods A retrospective analysis of146ADR reports was carried out,and the reports were reported to the National Adverse Drug Reaction Monitoring System in2016.Results In the146cases,male patients(55.85%)were more than female patients(43.15%).The age group of30-49years(36.99%)accounted for the largest proportion.ADR caused by antipsychotics were in the first position(74.66%),and the most frequently reported drugs associated with the ADR were haloperidol(17.81%),risperidone orally disintegrating tablets(13.01%)and clozapine(12.33%).The systems most commonly involved in ADR were nervous system(55.48%)in which mainly associated with extrapyramidal reaction(30.14%).The effect of ADR on the original disease was not obvious(91.78%).Conclusion The ADR are common in psychiatric inpatients,and attention should be paid to the ADR monitoring so as to ensure safe drug use.

关 键 词：抗精神病药物 药品不良反应 精神科 合理用药 

分 类 号：R969.3[医药卫生—药理学]