玻璃化对复苏囊胚移植单胎分娩结局的影响  

Influence of the Single Live Birth Outcome Following Transfer of Vitrified Blastocyst and Blastocyst Cultured from Thawing Cleavage Embryo

作　　者：刘寒艳[1] 陈仕萍[1] 杜红姿[1] 李莉[1] 陈蕊[1] LIU Han-yan;CHEN Shi-ping;DU Hong-zi;LI Li;CHEN Rui(Center for Reproductive Medicine,Third Affiliated Hospital of Guangzhou Medical University//Key Laboratory for Reproductive Medicine of Guangdong Province//Key Laboratory for Major Obstetric Diseases of Guangdong Province// Key Laboratory of Reproduction and Genetics of Guangdong Higher Education)

机构地区：[1]广州医科大学附属第三医院生殖医学中心//广东省生殖医学重点实验室//广东省产科重大疾病重点实验室//广东省普通高校生殖与遗传重点实验室,广东广州510150

出　　处：《中山大学学报（医学版）》2018年第2期238-244,共7页Journal of Sun Yat-Sen University:Medical Sciences

基　　金：广东省中医药局面上项目(20142097);广州医科大学青年项目(2014A18)

摘　　要：【目的】比较卵裂期胚胎复苏后囊胚培养移植与复苏嚢胚移植的单胎分娩结局,探讨最佳冻存方案。【方法】回顾性分析2014年1月至2016年10月在本中心行复苏周期移植(FET)并单胎分娩的患者,囊胚复苏组1 037个周期,卵裂胚复苏囊胚培养组690个周期。分析两组的新生儿分娩结局,其中包括平均孕周,平均体质量,男婴出生率,早产率,极早产率,低体质量率,极低体质量率,先天异常率。【结果】平均胎龄,新生儿平均体质量,活产、健康抱婴以及死胎的比例两组没有统计学差异(P>0.05)。出生性别比差异没有统计学意义;早产率,极早产率,低出生体质量率,极低出生体质量率以及先天异常率两组没有统计学差异(P>0.05);校正后,出生男婴率(AOR 1.07,95%CI 0.86~1.34),早产率(AOR 0.7,95%CI 0.49~1.01),极早产率(AOR 1.47,95%CI 0.55~3.96),低出生体质量率(AOR 1.38,95%CI 0.86~2.22),极低出生体质量率(AOR 0.76,95%CI 0.20~2.83)以及先天异常率(AOR 1.58,95%CI 0.66~3.76)两组仍然没有统计学差异(P>0.05)。【结论】新鲜囊胚冷冻后择期复苏移植能获得较好的新生儿结局,是目前较佳的囊胚培养和移植方案。【Objective】To compare the single live birth outcomes of blastocyst transfer between vitrified blastocyst and blastocyst cultured from thawing cleavage embryo,so as to choose the best scheme of blastocyst transfer.【Methods】Retrospective analysis of the single live birth clinical data of1037vitrified blastocyst compared with690blastocyst cul-tured from thawing cleavage embryo undergoing frozen embryo transplantation(FET)from January2014to October2016was performed.Mail outcome were including gestational age,neonatal weight,proportion of male neonate,preterm birthrate,very preterm birth rate,low birthweight rate,very low birthweight rate,congenital anomalies rate.【Results】There were no differences between the two groups for gestational age,neonatal weight,proportion of Live birth,health baby and stillbirth(P>0.05).There were no differences in proportion of male neonate(AOR1.07,95%CI0.86~1.34),preterm birth rate(AOR0.7,95%CI0.49~1.01),very preterm birth rate(AOR1.47,95%CI0.55~3.96),low birthweight rate(AOR1.38,95%CI0.86~2.22),very low birthweight rate(AOR0.76,95%CI0.20~2.83),congenital anomalies rate(AOR1.58,95%CI0.66~3.76,P>0.05).【Conclusion】The blastocyst may be the preferable stage for vitrifying and transfer currently which can obtain good neonatal outcomes

关 键 词：玻璃化冷冻 卵裂期胚胎 囊胚培养 囊胚移植 单胎分娩结局 

分 类 号：R321-33[医药卫生—人体解剖和组织胚胎学]