丙种球蛋白辅助治疗新生儿肺炎疗效分析  

Therapeutic effect of gamma globulin on neonate pneumonia

作　　者：胡孝成 刘宁[1] Hu Xiaocheng;Liu Ning(Jiujiang Maternal and Child Health Hospital, Department of Neonatology, Jiujiang, Jiangxi, 332000, China)

机构地区：[1]九江市妇幼保健院新生儿科,江西九江332000

出　　处：《当代医学》2018年第9期45-48,共4页Contemporary Medicine

摘　　要：目的探讨丙种球蛋白辅助治疗新生儿肺炎疗效。方法将2015年3月~2017年4月50例新生儿肺炎患儿作为对象根据随机信封法分组,各25例。对照组进行常规治疗,丙种球蛋白组采用丙种球蛋白辅助治疗。比较两组新生儿肺炎治疗效果;肺部啰音、咳嗽、气促消失时间、胸片X线阴影消失时间;干预前后患儿C反应蛋白、肿瘤坏死因子-α、白细胞介素-1β水平;治疗过程不良用药反应出现率;治疗前后免疫球蛋白水平。结果丙种球蛋白组新生儿肺炎治疗效果高于对照组(P<0.05);丙种球蛋白组肺部啰音、咳嗽、气促消失时间、胸片X线阴影消失时间短于对照组(P<0.05);干预前两组C反应蛋白、肿瘤坏死因子-α、白细胞介素-1β水平相近,差异无统计学意义;干预后丙种球蛋白组C反应蛋白、肿瘤坏死因子-α、白细胞介素-1β低于对照组(P<0.05)。两组患儿治疗过程不良用药反应均轻微,组间比较差异无统计学意义;干预前两组免疫球蛋白水平相近,差异无统计学意义;干预后丙种球蛋白组免疫球蛋白水平低于对照组(P<0.05)。结论丙种球蛋白辅助治疗新生儿肺炎疗效确切,可有效改善新生儿病情,缩短症状和体征消失时间,降低机体炎症因子水平,提高机体免疫力,且无明显不良反应,值得推广和应用。Objective To investigate the therapeutic effect of gamma globulin on neonate pneumonia.Methods From March2015to April2017,50infants with neonatal pneumonia were divided into two groups according to the random envelope method,25cases in each group.Control group for conventional treatment,gamma globulin group with gamma globulin adjuvant therapy.The therapeutic effect of neonatal pneumonia was compared between two groups.The time of pulmonary rales,cough,disappearance of shortness of breath,disappearance time of X-ray of chest radiograph,C-reactive protein,tumor necrosis factor-αand interleukin-The incidence of adverse drug reactions in the course of treatment;immunoglobulin levels before and after treatment.Results The therapeutic effect of gamma globulin in neonates with pneumonia was higher than that in the control group(P<0.05).The pulmonary rales,cough,disappearance of shortness of breath and disappearance of chest X-ray shadow in gamma globulin group were shorter than those in control group(P<0.05).The levels of C-reactive protein,tumor necrosis factor-αand interleukin-1βwere similar in the two groups before intervention,but the difference was not statistically significant.After intervention,the expressions of C-reactive protein,tumor necrosis factor-α,interleukin-1βwas lower than that of the control group(P<0.05).There was no significant difference between the two groups in the treatment of adverse drug reactions,there was no significant difference between the two groups,the difference was not statistically significant;before intervention,the immunoglobulin levels of the two groups were similar,with no significant difference;after intervention,immunoglobulin immunoglobulin levels Lower than the control group(P<0.05).Conclusion Gamma-globulin adjuvant treatment of neonatal pneumonia is effective and can effectively improve neonatal condition,shorten the symptoms and signs of disappearance time,reduce the level of inflammatory cytokines,improve immunity,and no obvious adverse reactions,it is worth promoti

关 键 词：丙种球蛋白辅助治疗 新生儿肺炎 疗效 

分 类 号：R722.135[医药卫生—儿科]