两种方法测定血液透析浓缩液中氯离子的含量研究  

Comparison of two methods for the determination of chloride in hemodialysis concentrate

作　　者：邹敏 彭东明[1] 彭俊英 李鸣 王福东[1] ZOU Min;PENG Dong-ming;PENG Jun-ying;LI Ming;WANG Fu-dong(College of Pharmacy,Hunan University of Chinese Medicine,Changsha 410208,China)

机构地区：[1]湖南中医药大学药学院,湖南长沙410208

出　　处：《应用化工》2018年第3期608-610,共3页Applied Chemical Industry

基　　金：湖南省科学技术厅科技计划一般项目(2014SK3024);药学湖南省重点学科开放基金项目(科函(2015)9号-5)

摘　　要：采用离子色谱法与离子计法测定血液透析浓缩液中氯离子的含量。以SH离子柱为色谱柱,以2 mmol/L Na_2CO_3和10 mmol/L NaHCO_3为流动相,流速1.5 mL/min,进样量为25μL,检测器为电导检测器。离子色谱法与离子计法分别在5~25 mg/L、600~3 000 mg/L范围内呈良好的线性关系,相关系数均大于0.999;平均加标回收率分别为99.67%,97.01%,RSD均小于2.0%。结果表明,两种方法均能快速、准确的测定血液透析浓缩液中氯离子的含量,且两者的测定结果无显著性差异。To determine the content of chloride in hemodialysis concentrate by ion chromatogramphy or ion meter.Ion chromatography was performed with SH ion column under 2 mmol/L Na 2CO 3 and 10 mmol/L NaHCO 3 as the mobile phase at a flow rate of 1.5 mL/min.The injection volume was 25μL and the detection was conductivity detector.Determination of chloride in hemodialysis concentrate all showed good linear relationship by ion chromatogramphy at the range of 5~25 mg/L or ion meter at the range of 600~3 000 mg/L,correlation coefficient“r”was all above 0.999.The rate of average addition standard recovery was 99.67%and 97.01%respectively,and the RSD was all less than 2.0%.The results show that both methods can determine the content of chloride in hemodialysis concentrate quickly and accurately and the results of the two methods show no significant difference.

关 键 词：离子色谱法 离子计法 氯离子 

分 类 号：TQ463.3[化学工程—制药化工] R917[医药卫生—药物分析学]