稽留流产患者8-异构前列腺素、超氧化物歧化酶、腺苷脱氨酶、转录因子κB和诱导型一氧化氮合酶表达情况及其临床意义  

Expression of 8-isoprostane,SOD,AOA,NF-κB and iNOS in Patients with Missed Abortion and Its Significance

作　　者：汪莉[1] 杨兆林[1] 陈茵[1] 石慧芬 WANG Li;YANG Zhao-lin;CHEN Yin;SHI Hui-fang(The Second People's Hospital of Nanhai District, Foshan(Nanhai Hospital of Guangdong General Hospital),Foshan 528251, China)

机构地区：[1]广东省佛山市南海区第二人民医院(广东省人民医院南海医院),528251

出　　处：《实用心脑肺血管病杂志》2017年第B12期76-77,共2页Practical Journal of Cardiac Cerebral Pneumal and Vascular Disease

基　　金：2017年佛山市科技计划项目(2017AB000102)

摘　　要：目的分析稽留流产患者8-异构前列腺素(8-isoprostane)、超氧化物歧化酶(SOD)、腺苷脱氨酶(AOA)、转录因子κB(NF-κB)、诱导型一氧化氮合酶(iNOS)表达情况及其临床意义。方法选取佛山市南海区第二人民医院2014年5月—2017年5月收治的稽留流产患者50例作为研究组,另选取同期正常妊娠者50例作为对照组。比较两组受试者血清及绒毛蜕膜组织中8-isoprostane、SOD、AOA、NF-κB、iNOS水平。结果研究组患者血清及绒毛蜕膜组织中8-isoprostane、NF-κB、iNOS水平高于对照组,SOD水平低于对照组(P<0.05);两组受试者血清和绒毛蜕膜组织中AOA水平比较,差异无统计学意义(P>0.05)。结论稽留流产患者血清和绒毛蜕膜组织中8-isoprostane、NF-κB、iNOS水平升高,SOD水平降低,其可作为稽留流产的预测因子。Objective To investigate the expression and significance of8-isoprostane,SOD,AOA,NF-κB and iNOS in patients with missed abortion.Methods From May2014to May2017,a total of55missed abortion patient were selected as study group,and50normal pregnant women were selected ascontrol group in Second People's Hospital of Nanhai District,Foshan.The serum and chorionic decidua tissue levels of8-isoprostane,SOD,AOA,NF-κB and iNOS were compared between the two groups.Results The levels of8-isoprostane,NF-κB and iNOS in the serum and chorionic decidua tissue of study group were statistically significantly higher than those of control group,the SOD was statistically significantly lower than that of control group(P<0.05);there was no difference in AOA levelin the serum and chorionic decidua tissue between the two groups(P>0.05).Conclusion The levels of8-isoprostane,NF-κB and iNOS were risein missed abortion patients,and SOD level was depress,these indexes can be used as predictive factors for missed abortion.

关 键 词：流产 稽留 8-异构前列腺素 超氧化物歧化酶 总抗氧化能力 转录因子κB 诱导型一氧化氮合酶 

分 类 号：R714.21[医药卫生—妇产科学]