芪桑降糖方对2型糖尿病大鼠血糖及肝功能的影响  

Effect of Qisang Hypoglycemic Formula on Blood Sugar and Liver Function of Type 2 Diabetic Mellitus Rats

作　　者：蒲秀瑛[1] 李海兵[1] 李晓玥[1] 李浩文[1] 续文君 PU Xiu-ying;LI Hai-bing;LI Xiao-yue;LI Hao-wen;XU Wen-jun(College of Life Science and Engineering,Lanzhou University of Technology Lanzhou Gansu Educational Department, The Key Lab of Screening,Evaluation and Advanced Processing of TCM and Tibetan Medicine,Lanzhou 730050,China)

机构地区：[1]兰州理工大学生命科学与工程学院,甘肃省中藏药筛选评价及深加工重点实验室,兰州730050

出　　处：《天然产物研究与开发》2018年第3期368-372,共5页Natural Product Research and Development

基　　金：国家自然科学基金(81260070)

摘　　要：本文采用高糖高脂饲料联合低剂量的链脲佐菌素(STZ)建立2型糖尿病大鼠模型,研究不同剂量的芪桑降糖方(Q-S,1.0 g/kg和0.5 g/kg)对2型糖尿病大鼠血糖及肝功能的影响。结果显示,Q-S可明显降低糖尿病大鼠空腹血糖(FBG)、血清谷丙转氨酶(ALT)、谷草转氨酶(AST)、糖原磷酸化酶(GP)、丙二醛(MDA)及糖化血清蛋白(GSP)含量(P<0.01),提高胰岛素敏感指数(ISI)、超氧化物歧化酶(SOD)、谷胱甘肽过氧化物酶(GSH-PX)及糖原合成酶(GS)活性(P<0.05,P<0.01)。这些结果表明,Q-S在降低糖尿病大鼠血糖的同时,还能有效地改善其肝功能。This study was performed to evaluate the influence of Qisang hypoglycemic formula(Q-S,1.0 g/kg and 0.5 g/kg)on blood glucose and liver function of type 2 diabetic mellitus rats induced by high-glucose-fat diet and low dose of STZ(35 mg/kg).The results showed that Q-S significantly decreased the levels of FBG,GP,ALT,AST,GSP and MDA compared with the diabetic mellitus model control group(P<0.01).Meanwhile,it was found that the levels of ISI,GS,SOD and GSH-PX were remarkably higher than that of the diabetic mellitus model control group(P<0.05,P<0.01).In conclusion,Q-S had an significant effect of lowering blood sugar on diabetic mellitus rats,and can improve the liver function simultaneously.

关 键 词：芪桑降糖方 糖尿病 STZ FBG 肝功能 

分 类 号：R966[医药卫生—药理学]