血胆红素和纤维蛋白原与2型糖尿病合并动脉粥样硬化性脑梗死的相关性  

Study on the correlation between type 2 diabetes mellitus and atherosclerotic cerebral infarction

作　　者：叶卫丰[1] 董丽华 张茜[1] 李靖[1] YE Wei-feng;DONG Li-hua;ZHANG Qian(Department of Clinical Laboratory,Beijing Friendship Hospital,Capital Medical University,Beijing 100050,China)

机构地区：[1]首都医科大学附属北京友谊医院检验科,北京100050

出　　处：《临床和实验医学杂志》2018年第6期607-610,共4页Journal of Clinical and Experimental Medicine

摘　　要：目的探讨血胆红素(TB)、纤维蛋白原(FIB)与2型糖尿病合并动脉粥样硬化性脑梗死的相关性。方法回顾性选取2015年4月至2016年8月首都医科大学附属北京友谊医院收治的2型糖尿病合并动脉粥样硬化性脑梗死患者60例,记为观察组。另取同期收治的非糖尿病动脉粥样硬化性脑梗死患者60例,记为对照组。分别比较两组患者的血清TB、血浆FIB水平。此外,对比观察组有无斑块、不同梗死面积以及神经功能缺损程度患者的TB、FIB水平。结果观察组TB水平为(13.77±3.9)μmol/L,显著低于对照组的(15.41±3.22)μmol/L,而FIB水平为(3.01±0.56)g/L,显著高于对照组的(2.74±0.45)g/L,均有显著性差异(P<0.05)。无斑块患者的TB水平显著高于有斑块患者,而FIB水平显著低于有斑块患者,差异均有显著性(P<0.05)。中小面积梗死患者的TB水平显著高于大面积梗死患者,而FIB水平显著低于大面积梗死患者,差异均有显著性(P<0.05)。神经功能轻度缺损患者的TB水平显著高于神经功能中重度缺损患者,而FIB水平显著低于神经功能中重度缺损患者,差异均有显著性(P<0.05)。结论血清TB与血浆FIB和2型糖尿病合并动脉粥样硬化性脑梗死患者的颈动脉有无斑块、梗死灶面积大小以及神经功能缺损存在密切相关,可作为临床上评估患者病情及预后的参考指标。Objective To explore the correlation between blood levels of total bilirubin(TB),fibrinogen(FIB)and type 2 diabetes mellitus complicated with atherosclerotic cerebral infarction.Methods A total of 60 patients with type 2 diabetes mellitus complicated with atherosclerotic cerebral infarction in this hospital during April 2015 to August 2016 were allocated in observation group and 60 patients with atherosclerotic cerebral infarction without diabetes mellitus were listed as control group.The blood levels of total bilirubin and fibrogen were compared between these 2 groups.In addition,the presence of plaques,difference in area of infarction as well as the degree of defect in nerve functions and the blood levels of bilirubin and fibrinogen were observed and compared between patients of these 2 groups.Results The average blood level of TB(13.77±3.9μmol/L)in patients of observation group was significantly lower than that(15.41±3.22μmol/L)of patients in control group,and the blood level of FIB(3.01±0.56 g/L)in patients of observtion group was significantly higher than that(2.74±0.45 g/L)of patients in control group,and their difference was significant(P<0.05).The blood level of TB in patients without plaque was significantly higher than that of patients with plaque,and their blood level of FIB was significantly lower than that of patients with plaque,and their difference was significant(P<0.05).The blood level of TB in patients with small and medium size of infarction was significantly higher than that of patients with large area of infarction,and their blood level of FIB was significantly lower than that of patients with large area of infarction,and the difference was significant(P<0.05).Neurofunction in patients with mild impairment was significantly higher than that of patients with moderately severe defect,and the blood levels of TB and FIB were significantly lower than those of patients with moderately severe defect in nerve function,and the difference was significant(P<0.05).Conclusion The blood levels of TB

关 键 词：2型糖尿病 动脉粥样硬化性脑梗死 胆红素 纤维蛋白原 相关性 

分 类 号：R587.1[医药卫生—内分泌] R743.33[医药卫生—内科学]