环磷酰胺导致的系统性红斑狼疮女性患者卵巢功能受损及闭经情况的分析  

Analysis of CTX caused SLE female patients impaired ovarian function amenorrhea

作　　者：何雪春[1] 张科[1] 李文根[1] 何春媚[1] HE Xuechun;ZHANG Ke;LI Wengen;HE Chunmei(Meizhou People′s Hospital,Meizhou,Guangdong 514031,China)

机构地区：[1]梅州市人民医院,广东梅州514031

出　　处：《安徽医药》2018年第4期762-765,共4页Anhui Medical and Pharmaceutical Journal

摘　　要：目的分析环磷酰胺(CTX)导致系统性红斑狼疮(SLE)女性患者卵巢功能受损及闭经情况。方法取2013年10月—2015年10月在该院治疗的SLE女性患者98例,均接受CTX治疗,观察患者卵巢功能受损及闭经发生的情况。结果98例患者中有51.02%出现卵巢功能受损,出现闭经者18.37%;患者治疗后雌二醇(E2)为(19.33±1.54)ng·L^(-1),明显较治疗前降低(P<0.05);患者治疗后血清促卵泡刺激素(FSH)、补体C3和补体C4分别为(21.50±2.41)IU·L^(-1)、(0.60±0.15)g·L^(-1)和(0.16±0.10)g·L^(-1),明显高于治疗前(P<0.05);>30~40岁组和>20~30岁组卵巢功能受损发生率分别为72.22%和52.38%,明显高于15~20岁组(P<0.05);>30~40岁组闭经发生率为38.89%,明显高于>20~30岁组和15~20岁组(P<0.05);>30~40岁组出现卵巢功能受损和闭经时CTX累积剂量分别为(14.30±0.83)g和(20.34±1.43)g,明显低于>20~30组(P<0.05)。结论CTX治疗SLE对卵巢功能有一定的损害作用,卵巢功能受损发生与患者年龄有一定关系,年龄大的患者出现卵巢功能受损时CTX累积剂量较低。Objective To investigate cyclophosphamide(CTX)impaired ovarian function and amenorrhea on female patients with systemic lupus erythematosus(SLE).Methods From October2013to October2015,98SLE patients in our hospital were selected,treated with CTX,observed in patients with impaired ovarian function and the incidence of amenorrhea.Results In98patients,51.02%were with ovarian dysfunction,18.37%with amenorrhea.After treatment,E2was(19.33±1.54)ng·L-1,which was significantly lower than that before treatment(P<0.05).After treatment,FSH,C3and C4were(21.50±2.41)IU·L-1,(0.60±0.15)g·L-1and(0.16±0.10)g·L-1,which were significantly higher than those before treatment(P<0.05);For>30-40years old and>20-30years old group,the incidence of impaired ovarian function was72.22%and52.38%,significantly higher than15-20years old group(P<0.05).>30-40years old group amenorrhea rate was38.89%,significantly higher than>20-30years old group and15-20years old group(P<0.05).>30-40years old group showed impaired ovarian function and amenorrhea when the cumulative dose of CTX were(14.30±0.83)g and(20.34±1.43)g,significantly lower than the>20-30years old group(P<0.05).Conclusion Treatment of SLE with CTX has a certain damage on ovarian function.There is a certain relationship between the occurrence of impaired ovarian function and the age of the patient.The older patients is with lower cumulative CTX dose when impaired ovarian function.

关 键 词：环磷酰胺 系统性红斑狼疮 卵巢功能受损 闭经 

分 类 号：R593.241[医药卫生—内科学]