血管内皮细胞自噬的调控机制及其对心血管疾病的影响  

Regulation mechanism of autophagy in vascular endothelial cells and its effects on cardiovascular diseases

作　　者：吴倩 龚国清[1] WU Qian;GONG Guoqing(Department of Pharmacology,China Pharmaceutical University^Nanjing 211198,China)

机构地区：[1]中国药科大学药理学研究室,江苏南京211198

出　　处：《药学研究》2018年第2期99-102,共4页Journal of Pharmaceutical Research

基　　金：国家自然科学基金(No.81373415)

摘　　要：血管内皮细胞自噬在多种心血管疾病如高血压、血栓栓塞及动脉粥样硬化等的发生和发展中扮演着重要角色,调控血管内皮细胞自噬反应可以减少这类疾病的发生。本文主要综述近年研究发现的参与血管内皮细胞自噬反应调控的通路和相关因子,以及血管内皮细胞自噬反应对心血管疾病的影响,为心血管疾病的防治提供新的思路。Autophag^^in endothelial cells plays important roles in several kinds of cardiovascular diseases such as hypertension,thrombosis,atherosclerosis and so on.These cardiovascular diseases can be depressed by modulating autophag^^in vascular endothelial cells.This paper mainly reviewed signal pathways and factors involving in regulating autophagy in vascular endothelial cells and its effects on cardiovascular diseases.In order to provide new ideas for prevention and treatment of cardiovascular diseases.

关 键 词：血管内皮细胞 自噬 心血管疾病 

分 类 号：R54[医药卫生—心血管疾病]