血清同型半胱氨酸与2型糖尿病患者冠状动脉病变SYNTAX评分的相关性研究  

Relationship between level of serum homocysteine and SYNTAX score in type 2 diabetic patients with coronary artery disease

作　　者：王伯乐 王焕霞[1] 徐金义[1] 韩雅琪 WANG Bo-le;WANG Huan-xia;XU Jin-yi;Han Yahan(Coronary Care Unit,the People′s Hospital of Henan Province,Fuwai Central China Cardiovascular Hospital,Zhengzhou 450000,China)

机构地区：[1]河南省人民医院,阜外华中心血管病医院冠心病重症监护室,郑州450000

出　　处：《中国临床新医学》2018年第3期221-223,共3页CHINESE JOURNAL OF NEW CLINICAL MEDICINE

基　　金：河南省科技厅科技计划项目(编号:152102310419)

摘　　要：目的探讨血清同型半胱氨酸(HCY)与2型糖尿病合并冠心病患者冠状动脉病变SYNTAX评分的相关性。方法选取2016-06~2017-06在该院治疗的2型糖尿病患者160例以及健康对照组80例。依据冠状动脉造影检查将2型糖尿病患者分为两组:无冠心病组80例,合并冠心病组80例。2型糖尿病合并冠心病组根据SYNTAX评分分为低危组23例、中危组30例、高危组27例。采用循环酶法检测研究对象血清HCY水平,并对比分析检测结果。结果 2型糖尿病无冠心病组和2型糖尿病合并冠心病组血清HCY检测水平高于健康组,2型糖尿病无冠心病组血清HCY水平低于2型糖尿病合并冠心病组;低危组和中危组组血清HCY水平均低于高危组,差异有统计学意义(P<0.05)。结论血清HCY水平与2型糖尿病合并冠心病患者SYNTAX评分紧密相关,血清HCY水平可作为判断2型糖尿病患者冠状动脉病变严重程度的指标。Objective To investigate the relationship between serum level of homocysteine and SYNTAX score in type 2 diabetic patients with coronary artery disease(CHD).Methods 160 patients with type 2 diabetes were chosen as the research subjects in our hospital between June 2016 and June 2017.80 healthy people were taken as the control group.According to the coronary arteriography,the 160 patients with type 2 diabetes were divided into two groups:type 2 diabetes without coronary heart disease group(n=80),type 2 diabetes with coronary heart disease group(n=80).According to SYNTAX scores,type 2 diabetes with coronary heart disease group was divided into low risk group(1~22 score,n=23),middle risk group(23~32 score,n=30)and high risk group(≥33 score,n=27).Results The levels of serum homocysteine in type 2 diabetes group and type 2 diabetes with coronary heart disease group were higher than those in the control group.The levels of serum homocysteine in the type 2 diabetes group were significantly lower than those in type 2 diabetes with coronary heart disease group,and the levels of serum homocysteine in the low risk group and middle risk group were significantly lower than those in the multi-branch lesion group(P<0.05).Conclusion The level of serum HCY is significantly associated with SYNTAX score in the patients with type 2 diabetes and coronary artery disease,suggesting that the level of serum HCY should be regarded as the reference index of the severity of coronary artery disease.

关 键 词：血清同型半胱氨酸 2型糖尿病 SYNTAX评分 冠心病 

分 类 号：R587.1[医药卫生—内分泌]