银川市中老年空腹血糖受损患者神经肽Y基因单核苷酸多样性表达  

Single nucleotide polymorphism of neuropeptide Y gene in middle and old age patients with impaired fasting blood glucose in Yinchuan City

作　　者：程羽萱 于晶晶[3] 黄琦[3] 马荣[3] 张旭[3] 王嘉[3] 田进海[3] 姜敏[3] YU Jing-jing;HUANG Qi;MA Rong;ZHANG X u;WANG Jia;TIAN Jin-hoi;JIANG Min;CHENG Yu-xuan(NingxiaMedical University Graduate School,Yinchuan 750004;Respiratory Department,BeijingZhongguancun Hospital,Beijing 100190;Ningxia Medical University General Hospital and Ningxia Sub Center of Biochip Beijing National EngineeringResearch Center,Yinchuan 750004,China)

机构地区：[1]宁夏医科大学研究生院,宁夏银川750004 [2]北京市中关村医院呼吸科,北京100190 [3]宁夏医科大学总医院暨生物芯片北京国家工程研究中心宁夏分中心,宁夏银川750004

出　　处：《临床医学研究与实践》2018年第9期1-2,8,共3页Clinical Research and Practice

基　　金：宁夏医科大学2015年宁夏高等学校科学研究资助项目(No.NGY2015076)

摘　　要：目的研究宁夏银川市中老年空腹血糖受损患者神经肽Y(NPY)基因单核苷酸多态性(SNP rs16147)表达。方法调查289名宁夏银川市40岁以上中老年人,通过实验室检查获取血脂、血糖等指标;检测SNP rs16147位点基因型及等位基因频率分布情况,并对正常及空腹血糖受损(IFG)者检测结果做对比分析。结果正常组和IFG组NPY基因SNP rs16147的基因型频率比较,差异显著(P<0.05)。结论空腹血糖受损患者rs16147位点的AA基因型突变率高于正常人。Objective To investigate the single nucleotide polymorphisms(SNP rs16147)of the neuropeptide Y(NPY)gene in normal middle and old age patients with impaired fasting blood glucose in Yinchuan.Methods A total of 289 people who were over 40 years old in Yinchuan were selected,and the blood lipids,blood glucose were tested through laboratory examination,and the genotype and SNP rs16147 allele frequency were detected,the test results of normal and impaired fasting blood glucose(IFG)patients were compared.Results The genotype frequency of the NYP gene SNP rs16147 in the normal group and IFG group were statistically different(P<0.05).Conclusion The mutation rate of AA genotype at rs16147 in patients with impaired fasting blood glucose is higher than that of the normal subjects.

关 键 词：中老年人 空腹血糖受损 神经肽Y(NPY) 单核苷酸多态性(SNPrs16147) 

分 类 号：R587.1[医药卫生—内分泌]