丹酚促吸收剂及滴丸制备研究  

Study of salvianolic sorbefacient and its preparation of dropping pills

作　　者：赵风至 陈思思[1] 刘利根[1] 石心红[1] ZHAO Fengzhi;CHEN Sisi;LIU Ligen;SHI Xinhong(Department of Traditional Chinese Medicine Preparations?China Pharmaceutical University,Nanjing 211198,China)

机构地区：[1]中国药科大学中药制剂教研室,南京211198

出　　处：《西北药学杂志》2018年第1期72-75,共4页Northwest Pharmaceutical Journal

摘　　要：目的筛选适宜的丹酚促吸收剂制剂质量浓度,优化丹酚滴丸的处方及制备工艺参数。方法采用大鼠在体单向肠灌流法考察不同质量浓度癸酸钠对丹酚的促吸收效果,通过单因素及正交优化,对丹酚配伍癸酸钠的滴丸处方及制备工艺进行优化。结果癸酸钠制剂促吸收比例为4.76%(质量/质量),最佳处方及工艺为PEG6 000∶PEG4 000=1∶4,药物基质比为1∶3,加水量10%(体积/质量),冷凝剂为二甲基硅油H201-500cs,熔融温度为80℃,滴距为4cm,滴径为2.5mm。结论所制备的丹酚滴丸圆整度高,崩解快,吸收效果好;优选的工艺方法简单且易重复,适宜工业化生产,质量可控。To select a proper sorbefacient concentration for salvianolic dropping pills and to optimize its formulation and process parameters.The in vivo uni-directional intestinal perfusion was used to inspect the transdermal effect of sodium caprate on salvianolic.The single factors and orthogonal experiment were used to filter the prescription and process.The promote density of sodium caprate was 4.7 6%,and the optimal conditions were PEG6 000:PEG4 00 0=1:4,drug matrix ratio of 1:3 and with water 10%,coolant of dimethicone H201-500 cs,material droplet system temperature 80°C,dripping distance 4 cm,and dropper inner diameter 2.5 mm.The prepared salvianolic dropping pills showed high roundness,fast disintegration,and higher bioavailability.The process is simple,easy to repeat,and suitable for industrial production.

关 键 词：促吸收剂 癸酸钠 丹酚滴丸 正交设计 

分 类 号：R944[医药卫生—药剂学]