锝[^(99)Tc]亚甲基二膦酸盐治疗骨质疏松症的研究进展  

Progress of Technetium [^(99)Tc] methylenedi-phosphonate in the treatment of osteoporosis

作　　者：秦艳娥[1] 陈彪[1] QIN Yane;CHEN Biao(Department of Pharmacy,Nanning First People s Hospital,Nanning 530022,China)

机构地区：[1]南宁市第一人民医院药学部,南宁530022

出　　处：《西北药学杂志》2018年第1期140-142,共3页Northwest Pharmaceutical Journal

基　　金：广西壮族自治区卫生和计划生育委员会自筹经费科研课题(编号:Z2015265)

摘　　要：目的分析概述锝[^(99)Tc]亚甲基二膦酸盐(^(99)Tc-MDP)治疗骨质疏松症(OP)的药理作用和临床应用研究进展。方法通过检索PubMed、CBM、CNKI、万方、维普等国内外数据库,归纳总结有关^(99)Tc-MDP治疗OP的药理作用和临床研究。结果^(99)Tc-MDP具有抑制破骨细胞活性、影响细胞因子表达、促进骨形成等作用,目前广泛应用于各种原发性和继发性骨质疏松症。结论 ^(99)Tc-MDP用于治疗OP具有疗效好、不良反应少等优点,值得临床进一步推广。To review the pharmacological effects and clinical application of Technetium[99Tc]methylenedi-phosphonate(99Tc-MDP)in the treatment of osteoporosis(OP).PubMed,CBM,CNKI and other domestic and foreign databases were used,the pharmacological effects and clinical application of99Tc-MDP treatment of OP were summarized.99T c-M D P has the effect of inhibiting the activity of osteoclast,affecting the expression of cytokines and promoting the bone formation,and is widely used in all kinds of primary and secondary OP.99Tc-MDP for the treatment of OP has the advantages of good curative effect and less adverse reaction,so it is worthy of further clinical promotion.

关 键 词：锝[99Tc]亚甲基二膦酸盐 骨质疏松症 药理作用 临床应用 

分 类 号：R97[医药卫生—药品]