调节性T细胞在白癜风发病机制中的作用及治疗应用  

Roles of Regulatory T Cells in the Pathogenesis of Vitiligo and Therapeutic Applications

作　　者：魏伟 何奕德 李萌 夏宇 隋秉东 高琳[4] 李凯[4] 刘玲[4] WEI Wei;HE Yi-de;LI Meng;XIA Yu;SUI Bing-dong;GAO Lin;LI Kai;LIU Ling(63888 Troop,The Chinese People’s Liberation Army,Jiyuan 454650,Henan,China;Department of Orthopaedics,Xijing Hospital,the Fourth Military Medical University,Xi'an 710032,Shaanxi,China;Sate Key Laboratory of Military Stomatology,School of Stomatology,The Fourth Military Medical University,Xi'an710032,Shaanxi,China;Department of Dermatology,Xijing Hospital,The Fourth Military Medical University,Xi'an 710032,Shaanxi,China)

机构地区：[1]解放军63888部队 [2]第四军医大学西京医院骨科 [3]第四军医大学口腔医院军事口腔医学重点实验室 [4]第四军医大学西京医院皮肤科

出　　处：《中国美容医学》2018年第1期133-136,共4页Chinese Journal of Aesthetic Medicine

基　　金：国家自然科学基金81101189;国家自然科学基金81773315

摘　　要：白癜风是一种临床常见的色素脱失性皮肤黏膜疾病,以表皮基底层黑色素细胞凋亡破坏为特点,发病机制复杂,治疗手段有限。白癜风的发病与免疫系统功能失调关联很大,其中自身免疫反应过度激活是其重要因素。在机体免疫系统中,CD4^+CD25^+FOXP3^+调节性T细胞(T regulatory cells,Tregs)发挥着调节免疫应答和维持免疫稳态的重要作用。研究显示,白癜风患者外周血中和皮损处的Tregs存在数量减少和功能减弱的现象。Tregs分泌免疫调节相关细胞因子水平下降,插头/翅膀状螺旋转录因子3(FOXP3)、细胞毒性T淋巴细胞表面抗原-4(CTLA-4)以及趋化因子CCL22均表达不良。因此,通过靶向恢复Tregs表达异常基因的治疗是当前白癜风研究的热点领域,此外,过继转移Tregs疗法已在白癜风动物模型上取得了一定的疗效。进一步阐明Tregs在白癜风发病机制中的具体作用,探索Tregs靶向治疗方法,将为白癜风的预防和治疗提供新思路。Vitiligo is a kind of common pigmented dermatoseswith high prevalence but limited therapeutic options.It is characterized by apoptotic damage of melanocytes of the basal layers of the epidermis resulted from a complicated pathogenesis.The development of vitiligo is associated withthe dysfunction of the immune system,especially the overactivation of the auto-immune reaction.In the immune system,CD4+CD25+FOXP3+regulatory T cells(Tregs)play significant roles in the modulation of immune responses and the maintenance of the immune homeostasis.Recent studies have demonstrated the decrease in the values and activities of Tregs in the peripheral blood and the skin lesions of patients with vitiligo.Furthermore,the immunoregulation-related cytokines secreted by Tregs are reduced,while the expression of FOXP3,CTLA-4 and CCL22 decrease.Therefore,target therapy for the abnormal gene expression of Tregs is a hotspot of current researches in the treatment of vitiligo.In addition,studies found that the adoptive transfer of Tregs induced vitiligo amelioration in mice.On the basis of these studies,further elucidating the function of Tregs in the pathogenesis of the vitiligo and improving Tregs-targeted therapeutic approaches will provide new ideas in the prevention and management of the vitiligo.

关 键 词：TREGS 调节性T细胞 白癜风 自身免疫反应 FOXP3 

分 类 号：R758.41[医药卫生—皮肤病学与性病学]