雷贝拉唑联合多潘立酮混悬液辅助治疗反流性食管炎致支气管哮喘的临床研究  

Clinical study on bronchitis asthma with reflux esophagitis

作　　者：杨慧[1] 白青山[1] 高慧[1] 艾智慧[1] YANG Hui;BAI Qing-shan;GAO Hui;AI Zhi-hui(Tangshan Maternal and Child Health Care Hospital,Tangshan,Hebei　063000,China[)

机构地区：[1]唐山市妇幼保健院,河北唐山063000

出　　处：《临床肺科杂志》2018年第2期301-304,共4页Journal of Clinical Pulmonary Medicine

摘　　要：目的研究反流性食管炎致支气管哮喘的临床治疗。方法将我院在2016年5月至2016年11月收治的反流性食管炎合并支气管哮喘的患儿127例,按照对照、随机、双盲的分配原则,将所有患儿分为治疗组(n=64)及对照组(n=63)。治疗组在常规治疗哮喘方案上加用质子泵抑制剂及消化道促动力剂,对照组采用常规治疗哮喘方案加用消化道促动力剂治疗。观察两组的不同治疗效果。结果治疗前两组患儿的肺功能各参数差异不明显(P>0.05)。治疗后,治疗组改善较为明显,且显著优于对照组水平,具有统计学意义的差异(P<0.05)。治疗组食管pH小于4的反流次数及总时间百分率分别为(42.35±5.36)次、(5.84±1.25)%,明显低于对照组水平,差异具有统计学意义(P<0.05)。治疗组治疗总体有效率高达89.06%,对照组仅为66.67%,差异较为明显,具有统计学意义(P<0.05)。结论临床上治疗反流性食管炎致支气管哮喘时,需更加注重病因治疗,辅加质子泵抑制剂及消化道促动力剂可显著改善治疗效果,值得推广使用。Objective To explore the clinical treatment on bronchitis asthma with reflux esophagitis.Methods All patients were treated with reflux esophagitis with bronchial asthma from May 20 to November 2016.All patients were assigned to the treatment group according to the control,randomized,double-blind distribution principle(n=64)and control group(n=63).The control group was treated with conventional asthma regimen and digestive tract.On the basis of this,the treatment group was supplemented with proton pump inhibitor and digestive tract.The different therapeutic effect of the two groups was analyzed.Results There was no significant differences in lung function between the two groups before treatment(P>0.05).After treatment,the improvement of the treatment group was more obvious,and significantly better than the control group(P<0.05).The percentage of reflux and total time of esophageal pH less than 4 were(42.35±5.36)and(5.84±1.25)%,respectively,which was significantly lower than that of the control group(P<0.05).The overall effective rate was 89.06%in the treatment group and 66.67%in the control group(P<0.05).Conclusion The clinical treatment of bronchitis asthma caused by reflux esophagitis should be paid more attention to the cause of treatment,combined with proton pump inhibitor and gastrointestinal motility agent,it can significantly improve the treatment effect,which is worth promoting the application.

关 键 词：反流性食管炎 支气管哮喘 治疗 

分 类 号：R562.25[医药卫生—呼吸系统] R571[医药卫生—内科学]