RBP联合尿液蛋白检测对慢性肾小球肾炎预后的评估  

Assessment of Renal Impairment and Prognosis in Patients with Chronic Glomerulonephritis by Serum Retinol binding Protein and Urine Alpha 1 Microspheres and Microalbuminuria

作　　者：徐磊霞 许琴[2] 曹娟[2] XU Leixia;XU Qin;CAO Juan(Department of clinical laboratory,Rugao people's Hospital 2265002)

机构地区：[1]江苏省如皋市人民医院检验科,226500 [2]泰兴市人民医院肾内科

出　　处：《临床输血与检验》2018年第1期54-56,61,共4页Journal of Clinical Transfusion and Laboratory Medicine

基　　金：江苏省卫生计生委科研项目(No.Z201525);泰兴市人民医院院级课题(No.try1615)资助

摘　　要：目的分析血清视黄醇结合蛋白(RBP)和尿液α1微球蛋白(α1-MG)、微量白蛋白(mALB)联合检测在慢性肾小球肾炎患者肾功能损害及预后效果评估中的应用价值。方法在本院2013年12月~2014年12月实施治疗的慢性肾小球肾炎患者中随机选取50例为研究对象(观察组),同时随机选取同期体检健康者50例为对照组,检测两组的RBP、α1-MG以及mALB,分析以上指标在患者肾脏功能损害及预后效果评估中的应用价值。结果和对照组相比,观察组患者的RBP、α1-MG以及mALB水平明显偏高,差异有统计学意义(t=8.6225、9.3614、11.2416,P<0.05);慢性肾功能衰竭患者的RBP、α1-MG及mALB水平明显高于病情缓慢或无进展患者,差异有统计学意义(t=7.9854、8.6354、10.5241,P<0.05),RBP、α1-MG以及mALB水平变化和患者预后效果成正比;和三项指标单独检测评估相比,RBP、α1-MG以及mALB联合检测的ROC曲线下面积、敏感性以及特异性均明显偏高。结论RBP、α1-MG以及mALB三项指标在慢性肾小球肾炎患者肾功能损害以及预后效果评估中具有重要的应用价值,其中三项指标联合检测更有助于提高临床评估准确率,值得推广应用。Objective To study significance of combined detection of serum retinol binding protein(RBP)and urine alpha 1 microglobulin(alpha 1-MG),albumin(mALB)in assessment of renal function and prognosis in patients with chronic glomerulonephritis.Methods The 50 cases were randomly selected from patients with chronic glomerulonephritis undergoing implementation method of treatment as the research object in our hospital in December 2 0 1 3-2 0 1 4 year in December,as the observation group,and randomly 50 cases of healthy persons were selected as control group at the same period.RBP,1-MG and mALB alpha were detected in two groups,the correlation between above indicators and the damage of kidney function or prognosis of patients were analyzed.Results Compared with the control group,there was higher level of RBP,a 1-MG and mALB in patients from the observation group with significantlydifference(t=8.6225,9.3614,11.2416,P<0.05);RBP,mALB and alpha 1-MG levels were significantly higher in patients with chronic renal failure than in those slow or no progress(t=7.9854,8.6354,10.5241,P<0.05),the change of RBP,alpha 1-MG and mALB level is proportional to the prognosis effect;and compared to separate evaluation,sensitivity and specificity are significantly higher in ROC of RBP,a 1-MG and mALB curve of joint detection area.Conclusion Three indexes of RBP,1-MG and mALB alpha has important application value in the evaluation of renal function in patients with chronic glomerulonephritis damage effect and prognosis,and three indicators combined detection is helpful to improve the accuracy of clinical assessment,it is worthy of popularization and application.

关 键 词：血清视黄醇结合蛋白 尿液α1微球蛋白 微量白蛋白 慢性肾小球肾炎 肾功能损害 预后 

分 类 号：R446.11[医药卫生—诊断学] R692.31[医药卫生—临床医学]