外泌体参与骨骼肌机能调控研究进展  

Progress on Exosomes and Its Role in Skeletal Muscle Function Regulation

作　　者：杨东丽 杨琼[2] 罗嘉[1] 谭娅[1,3] 蒲红州[4] 张顺华 朱砺[1] YANG Dong-li;YANG Qiong;LUO Jia;TAN Ya;PU Hong-zhou;ZHANG Shun-hua;ZHU Li(College of Animal Science and Technology,Sichuan Agricultural Uniersity,Chengdu,Sichuan,611130,China;Chengdu Vocational College of Agricultural Science and Technology,Chengdu,Sichuan,6111305,China;Nanjiang County Agricultural Bureau of Sichuan Province,Nanjiang,Sichuan,635600,China;Institute of Animal Science and Veterinary Medicine,Guiyang,Guizhou,550005,China)

机构地区：[1]四川农业大学动物科技学院,四川成都611130 [2]成都农业科技职业学院,四川成都6111305 [3]贵州省畜牧兽医研究所,贵州贵阳550005 [4]四川省南江县农业局,四川南江635600

出　　处：《动物医学进展》2018年第1期103-108,共6页Progress In Veterinary Medicine

基　　金：四川省科技支撑计划项目(16ZC2838;2015NZ0013;2016NZ0089);四川省科技富民强县专项行动计划项目;四川省教育厅科研项目(16ZB0038)

摘　　要：骨骼肌与动物体健康及产肉动物的生产性能有着密切的联系。骨骼肌的生长发育是一个非常复杂的生物学过程,受到多种因素的调控。外泌体(exosomes)又称外泌小体,是一种由活细胞分泌的直径在30nm^100nm的膜性小囊泡,含有细胞特异性的蛋白质、脂质和核酸,能作为信号分子传递给其他细胞从而改变受体细胞的功能,在细胞间物质和信息传递中起重要作用。论文就外泌体的发现与应用、分离与鉴定及其参与骨骼肌生长发育、再生和肌肉萎缩等过程中的调控作用的研究进展进行综述,以期为骨骼肌生长发育机制及相关疾病的研究提供参考。Exosomes are small extracellular vesicles(30-100 nm diameter),which derived from almost all kinds of mammal cells under diverse physiological and pathological conditions.Exosomes carry a variety of biological ingredients,such as proteins,lipids,mRNA and miRNA,which are related to donor cells.Hence it plays an important role in modulating the behavior of target cells by changing intercellular substance and communication.In this paper,we reviewed the discovery and application,isolation and identification and its involvement in skeletal muscle growth and development,regeneration and muscle atrophy,providing a reference for the study of skeletal muscle growth and development mechanism and related diseases.

关 键 词：外泌体 MIRNA 骨骼肌 肌肉再生 肌肉萎缩 

分 类 号：S852.21[农业科学—基础兽医学]