2例犬骨母细胞型骨肉瘤的诊治  

Diagnosis and Treatment of Two Cases of Canine Osteoblast Osteosarcoma

作　　者：杜晓鹏 徐陶 毛爱国 张崇林 党西锋 王雄[3] DU Xiao-peng;XU Tao;MAO Ai-guo;ZHANG Chong-lin;DANG Xi-feng;WANG Xiong(Kunming Police Dog Base,Ministry of Public Security,Kunmuing,Yunnan,650204,China;Police Dog Base of Sichuan Public Security Department,Chengdu,Sichuan,610000,China;Municipal Public Security Police Dog Team,Guangyuan,Sichuan,628000,China)

机构地区：[1]公安部昆明警犬基地,云南昆明650204 [2]四川省广元市公安局警犬队,四川广元628000 [3]四川省公安厅警犬基地,四川成都610000

出　　处：《动物医学进展》2018年第1期129-133,共5页Progress In Veterinary Medicine

摘　　要：2015年—2017年,笔者在临床上遇到2例犬骨母细胞型骨肉瘤。2例骨肉瘤分别发生在桡骨和肱骨,并在后期出现肺转移,发生恶变。临床特征包括患部肿胀、变硬,随病程延长患部扩大;X光拍片和CT扫描,可见骨骼溶解。解剖可见骨骼及周围肌肉组织溶解,呈灰黄色及灰褐色;病灶中央出现囊状膨胀性骨质破坏,溶解组织呈紫红色,有砂砾样感;病变造成部分骨骼组织缺失,病灶与附近骨骼组织界限清晰。组织病理特征包括大量的骨母细胞呈弥漫性浸润,间质中可见丰富的血管;丰富的骨样组织(基质)互相连接成条索状,形成排列规则的骨小梁;恶变后,细胞异型性明显,出现多核细胞。在病灶反应区外的广泛性大块手术切除,可能是早期治疗的有效方法。From 2015 to 2017,the author encountered 2 cases of canine osteoblast osteosarcoma.Two cases of osteoblast osteosarcoma occurred in the radius and humerus,and the pulmonary metastasis occurred in the later stage.The clinical features included:swelling of the affected part,hardening,and extension of the disease with the duration of the disease;X-ray and CT scan showed the bone dissolving.Anatomical visible bone and surrounding muscle tissue dissolved in grayish yellow and grayish brown;In the center of the lesion,cystic dilatation of bone was found in the center of the lesion.The lesion caused partial bone tissue loss,and the lesion had clear demarcation from the nearby bone tissue.The histopathological features included:a large number of osteoblasts present diffuse infiltration and abundant blood vessels in the interstitium.The rich osteoid tissue(stroma)is attached to each other to form a line,forming the bone trabeculae.After the malignant transformation,cell heteromorphism was obvious and multinuclear cells appeared.Extensive extensive surgical resection of the lesions outside the focal area may be an effective method for early treatment.

关 键 词：犬 骨母细胞型 骨肉瘤 囊状骨质破坏 骨样基质 骨小梁 

分 类 号：S858.292[农业科学—临床兽医学] S857.4[农业科学—兽医学]