中医药治疗糖尿病皮肤瘙痒症临床效果Meta分析  

Clinical Effect of Traditional Chinese Medicine in Treatment of Patients with Diabetic Pruritus:a Meta-analysis

作　　者：潘毅[1] 刘文君[2] 李兰芝 陈贝贝 徐丽梅[1] PAN Yia;LIU Wenjun;LI Lanzhi;CHEN Beibei;XU Limei(Department of Dermatology General Hospital of PLA Air Force,Beijing 100142,China;Department of Traditional Chinese Medicine,General Hospital of PLA Air Force,Beijing 100142,China)

机构地区：[1]空军总医院皮肤病医院,北京100142 [2]空军总医院中医科,北京100142

出　　处：《解放军医药杂志》2018年第1期13-18,共6页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：首都临床特色应用研究课题(Z121107001012011)

摘　　要：目的评价中药治疗糖尿病皮肤瘙痒症(DP)的有效性和安全性。方法检索Cochrane、Pub Med、SCI、Embase、Wiley、Ovid、CNKI、VIP、CBM数据库建库至今以中药治疗DP的临床随机对照研究(RCT)进行系统评价。结果最终共纳入15篇RCT进行Meta分析。结果显示,中药治疗可提高DP有效率[OR=5.59,95%CI(3.85,8.11)]和治愈率[OR=3.03,95%CI(2.24,4.10)],降低血糖水平[OR=-0.37,95%CI(-0.51,-0.24)],缓解瘙痒症状[OR=-1.26,95%CI(-1.47,-1.06)],且无明显不良反应事件发生。结论中药治疗可提高DP临床效果,降低血糖水平,缓解瘙痒症状,且安全性较好,但其远期疗效及安全性有待开展更多高质量、大样本、长期随访的RCT加以验证。Objective To investigate efficiency and safety of traditional Chinese medicine(TCM)in treatment of patients with diabetic pruritus(DP).Methods Clinical randomized controlled trials(RCT)of TCM in treatment of patients with DP were retrieved for system evaluation in Cochrane,PubMed,SCI,Embase,Wiley,Ovid,CNKI,VIP and CBM databases from database establishment till now.Results A total of 15 RCTs were included for meta-analysis.Results showed that TCM therapy could improve efficiency rate[OR=5.59,95%CI(3.85,8.11)]and cure rate[OR=3.03,95%CI(2.24,4.10)],decrease blood glucose level[OR=-0.37,95%CI(-0.51,-0.24)]and relieve itching symptoms[OR=-1.26,95%CI(-1.47,-1.06)]of diabetic pruritus,and no obviously adverse events were found.Conclusion TCM therapy can improve clinical efficacy,reduce blood sugar levels and relieve itching symptoms with good safety,but its long-term efficacy and safety need to be proved by further high-quality,large samples and long-term follow-up RCT.

关 键 词：糖尿病并发症 瘙痒症 中药疗法 随机对照试验 META分析 

分 类 号：R587.29[医药卫生—内分泌] R256[医药卫生—内科学]