水通道蛋白1,3在变应性鼻炎大鼠鼻黏膜的表达及促鼻内腺体分泌的研究  

Aquaporin 1,3 Expressions in Nasal Mucosa Tissues of Rats with Allergic Rhinitis and Promotion of Nasal Glands Secretion

作　　者：许敏达[1] XU Min da(Department of ENT,Head and Neck Surgery,Zhejiang Hospital,Hangzhou 310013,China)

机构地区：[1]浙江医院耳鼻咽喉-头颈外科,浙江杭州310013

出　　处：《解放军医药杂志》2018年第1期46-48,共3页Medical & Pharmaceutical Journal of Chinese People’s Liberation Army

基　　金：浙江省医药卫生科技计划项目(2015DTA001)

摘　　要：目的探讨水通道蛋白1,3(aquaporin 1,3,AQP1,3)在变应性鼻炎大鼠鼻黏膜的表达及其促鼻内腺体分泌的作用机制。方法 40只健康大鼠随机分为对照组和实验组,每组20只。对照组大鼠腹腔注射等量生理盐水,实验组大鼠制备变应性鼻炎模型。观察两组大鼠血清离子浓度,鼻黏膜AQP1,3表达情况及鼻内腺体分泌量。结果实验组血清Ca2+和K+浓度较对照组降低,Na+浓度较对照组升高(P<0.01)。实验组AQP1,3在鼻黏膜表达面积和鼻内腺体分泌量较对照组增加(P<0.05)。结论 AQP1,3在变应性鼻炎大鼠鼻黏膜的表达增强,且表达上调可能会影响鼻内腺体的分泌量。Objective To investigate aquaporin 1 and 3(AQP1,3)expressions in nasal mucosa tissues of rats with allergic rhinitis and its action mechanism of promoting nasal glands secretion.Methods A total of 40 healthy rats were randomly divided into control group and experimental group(n=20 for each group).Control group was intraperitoneally injected with the same volume of physiological saline,while rats in experimental group were established allergic rhinitis models.Serum ion concentration,AQP1,3 expressions in nasal mucosa tissues and secretion volumes of nasal glands were detected in two groups.Results Compared with those in control group,serum Ca 2+and K+concentrations were significantly decreased,while Na+concentration was significantly increased in experimental group(P<0.01).AQP1,3 values of expression areas and secretion volumes of nasal glands in experimental group were significantly increased than those in control group(P<0.05).Conclusion AQP1,3 expressions in nasal mucosa tissues of rats with allergic rhinitis are increased,and the increased AQP1,3 expressions may be affected secretion volumes of nasal glands.

关 键 词：变应性鼻炎 水通道蛋白1 3 鼻内腺体 大鼠 

分 类 号：R765.21[医药卫生—耳鼻咽喉科] R-332[医药卫生—临床医学]