肝脏快速容积采集动态增强扫描对前列腺癌的诊断价值及与血管生成对照分析  

Value of LAVA technology applied to the diagnose of prostate cancer and the comparison with angiogenesis

作　　者：陈龙兴[1] 金东虎[1] 唐震[1] 程鸣[1] 李跃华[1] 李晓兵 盛友华[2] 金纪忠[3] 黄锋 戴群花[1] 陈凤光 吴世明[1] 旷小春[1] 刘晓航[4] CHEN Longxing;JIN Donghu;TANG Zhen;CHENG Ming;LI Yuehua;LI Xiaobing;SHENG Youhua;JIN Jizhong;HUANG Feng;DAI Qunhua;CHEN Fengguang;WU Shiming;KUANG Xiaochun;LIU Xiaohang(Department of Radiology,Shanghai Fengxian District Central Hospital,Shanghai Jiao Tong University Affiliated Sixth People’s Hospital South Campus,Shanghai,201499,China.)

机构地区：[1]上海交通大学附属第六人民医院南院奉贤区中心医院放射科,上海201499 [2]上海交通大学附属第六人民医院南院奉贤区中心医院病理科,上海201499 [3]上海交通大学附属第六人民医院南院奉贤区中心医院泌尿科,上海201499 [4]复旦大学医学院附属肿瘤医院放射科,上海200032

出　　处：《中国中西医结合影像学杂志》2018年第1期22-25,共4页Chinese Imaging Journal of Integrated Traditional and Western Medicine

基　　金：上海市奉贤区科委资助项目(奉科20131403)

摘　　要：目的:探讨肝脏快速容积采集技术(LAVA)动态增强扫描对前列腺癌的诊断价值,并结合病理初步分析前列腺病变与血管生成的相关关系。方法:回顾性分析经穿刺活检及手术病理证实的前列腺癌和前列腺增生各40例的MRI表现,术前均行MRI常规平扫和LAVA动态增强扫描,观察病灶LAVA动态强化特征并获得TIC,分析其参数变化,同时对证实的病理标本行血管内皮生长因子(VEGF)和微血管密度(MVD)测定。结果:病变TIC分为3型:Ⅰ型为缓慢强化型,Ⅱ型为平台型,Ⅲ型为速升下降型;Ⅰ型多见于前列腺增生,Ⅱ型既可见于前列腺癌,又可见于前列腺增生,Ⅲ型以前列腺癌为主。前列腺癌组病灶强化峰值时间早于前列腺增生组,强化程度和强化率均高于前列腺增生组(均P<0.05)。前列腺癌组MVD值及VEGF表达明显高于前列腺增生组(均P<0.05)。结论:LAVA动态增强扫描强化特征有助于前列腺增生与前列腺癌的诊断与鉴别诊断,且能反映前列腺癌及前列腺增生血管生成的不同状况。Objective:To evaluate the value of LAVA in the diagnosis of prostate cancer and analyze preliminarily the pathological changes of prostate and angiogenesis with reference of pathology.Methods:The MRI findings of 40 patients with prostate cancer and 40 patients with benign prostatic hyperplasia.All the patients had routine plain MRI and LAVA multi-phase dynamic contrast enhanced scanning before operation.The LAVA dynamic enhanced features were observed,and TIC were obtained,and the changes of the parameters were analyzed.Vascular endothelial growth factor(VEGF)and microvessel density(MVD)of all cases were determined.Results:TIC were classified into three types.Type I was persistently and slowly ascending curve,type II was flat type curve and type III was rapidly ascending and descending curve.Type I most appeared in benign prostatic hyperplasia(BPH),type II most appeared in both prostate cancer and BPH,and type III most appeared in prostate cancer.Peak time of prostate cancer was earlier than that of BPH.The enhancement degree and enhancement rate of prostate cancer were higher than those of BPH(all P<0.05).MVD value and VEGF expression of prostate cancer were significantly higher than those of BPH(all P<0.05).Conclusions:LAVA dynamic enhanced features helps to the diagnosis and the differential diagnosis between BPH and prostate cancer,and it can reflect the different conditions of the prostate cancer and BPH angiogenesis.

关 键 词：前列腺肿瘤 前列腺增生 磁共振成像 血管内皮生成因子类 

分 类 号：R445.2[医药卫生—影像医学与核医学] R737.25[医药卫生—诊断学]