凝血指标及ANC在儿童淋巴瘤化疗前后的变化及其临床意义  

Coagulation index and ALC in children with lymphoma before and after chemotherapy changes and its clinical significance

作　　者：吴攀[1] 张琴 WU Pan;ZHANG Qin(Department of Hematology,Hunan Children′s Hospital,Changsha,Hunan 410000,China;Department of Pharmacy,the First Hospital of Hunan University of Chinese Medicine,Changsha,Hunan 410000,China)

机构地区：[1]湖南省儿童医院血液内科,湖南长沙410000 [2]湖南省中医药大学附属第一医院制剂中心,湖南长沙410000

出　　处：《国际检验医学杂志》2018年第3期271-273,277,共4页International Journal of Laboratory Medicine

基　　金：湖南省自然科学基金(09JJ6029)

摘　　要：目的探讨凝血指标及中性粒细胞绝对计数(ANC)在儿童淋巴瘤化疗前后的变化及其临床意义。方法将该院2013年2月至2016年2月收治的淋巴瘤患儿80例作为观察组,另外选择同期健康体检儿童50例作为对照组。比较两组患儿的凝血酶原时间(PT)、纤维蛋白原(FIB)、活化部分凝血活酶时间(APTT)及ANC指标水平。结果观察组患儿凝血功能及ANC水平明显高于对照组,差异明有统计学意义(P<0.05)。淋巴瘤Ⅰ~Ⅱ期患儿凝血功能及ANC水平与Ⅲ~Ⅳ期患儿比较差异无统计学意义(P>0.05)。化疗有效患儿化疗后凝血功能及ANC水平明显低于化疗前,差异有统计学意义(P<0.05)。化疗无效患儿化疗后凝血功能及ANC水平与化疗前相比差异无统计学意义(P>0.05)。结论凝血功能及ANC水平与淋巴瘤患儿化疗疗效存在相关性,淋巴瘤患儿化疗过程中检测凝血功能及ANC水平有助于血栓形成的发现及预防出血。Objective To explore the changes of coagulation index and absolute neutrophil count(ANC)before and after chemotherapy in lymphoma and its clinical significance.Methods 80 cases of lymphoma children admitted in our hospital from February 2013 to February 2016 were selected as the observation group,In addition,50 healthy subjects were enrolled as control group.The levels of prothrombin time(PT),fibrinogen(FIB),activated partial thromboplastin time(APTT),ANC were compared between the two groups.Results The levels of coagulation,ANC in the observation group were significantly higher than those in the healthy control group,the difference was statistically significant(P<0.05).There were no significant differences in coagulation function,ANC levels between children with stageⅠandⅡ(P>0.05).There was no significant difference between the two groups(P>0.05).The levels of coagulation,ANC in children with chemotherapy were significantly lower than those before chemotherapy(P<0.05).There was no significant difference in coagulation function,ANC level between chemotherapy group and chemotherapy group before chemotherapy(P>0.05).Conclusion Coagulation function and ANC levels are correlated with chemotherapy efficacy in children with lymphoma.Detection of coagulation function and ANC level during chemotherapy is helpful for finding and preventing bleeding in children with lymphoma.

关 键 词：淋巴瘤 高凝状态 血栓 化疗 中性粒细胞绝对计数 

分 类 号：R446.11[医药卫生—诊断学]