采用ROC曲线分析促甲状腺激素和甲状腺激素对甲状腺癌的鉴别意义  

Analysis of the significance of thyroid stimulating hormone and thyroid hormone in thyroid carcinoma by ROC curve

作　　者：张雨[1] 马亚凌 娜迪热.铁列吾汗 ZHANG Yu;MA Yaling;NADIRE·Tieliewuhan(Department of Health Management Center,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China;Department of Ultrasound,First Affiliated Hospital of Xinjiang Medical University,Urumqi,Xinjiang 830054,China)

机构地区：[1]新疆医科大学第一附属医院健康管理中心,乌鲁木齐830054 [2]新疆医科大学第一附属医院超声科,乌鲁木齐830054

出　　处：《国际检验医学杂志》2018年第3期296-299,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金(81360592)

摘　　要：目的探讨促甲状腺激素和甲状腺激素对甲状腺癌和甲状腺良性病变的诊断及鉴别的作用。方法采用ROC曲线分析的方式,对该院入选的70例甲状腺癌患者(甲状腺癌组)和70例甲状腺良性病变患者(甲状腺良性病变组)进行分析,通过对患者血清促甲状腺激素(TSH)、游离甲状腺素(FT4)及游离三碘甲状腺原氨酸(FT3)的水平进行检测,对两组进行比较,再通过ROC曲线分析分析其对甲状腺癌和甲状腺良性病变的诊断价值及鉴别意义。结果甲状腺癌组TSH水平要显著性高于甲状腺良性病变组,而FT3和FT4水平要显著性低于甲状腺良性病变组,差异有统计学意义(P<0.05)。ROC曲线分析结果显示,以甲状腺癌为对角线,TSH曲线下面积为0.800,临界点为TSH 4.55μIU/mL。以甲状腺良性病变为对角线,FT3曲线下面积为0.791,临界点为3.25ng/mL,FT4曲线下面积为0.861,临界点为1.54ng/dL。结论可将TSH、FT3和FT4运用到甲状腺癌和甲状腺良性病变鉴别中。Objective To investigate the role of thyroid stimulating hormone and thyroid hormone in the diagnosis and differential diagnosis of thyroid carcinoma and thyroid benign lesions.Methods Using ROC curve analysis,70 cases of thyroid cancer patients(sthyoid cancer group)and 70 cases of benign thyroid lesions(benign thyoid disease group)in the hospital were enrolled in the study and analyzed,serum TSH,FT 4 and FT 3 levels were measured.The value of ROC curve in the diagnosis and differential diagnosis of thyroid carcinoma and thyroid benign lesions was analyzed.Results The level of TSH in thyroid cancer group was significantly higher than that in benign thyroid disease group,while the levels of FT 3 and FT 4 were significantly lower than those of benign thyroid lesions(P<0.05).ROC curve analysis showed that the area under the TSH curve was 0.800,and the critical point was TSH 4.55μIU/mL,with thyroid cancer as a diagonal.With benign thyroid lesions as the diagonal,the area under the FT 3 curve was 0.791,the critical point was 3.25 ng/mL,the area under the FT 4 curve was 0.861,and the critical point was 1.54 ng/dL.Conclusion TSH,FT 3 and FT 4 can be used in the differential diagnosis of thyroid cancer and thyroid benign lesions.

关 键 词：促甲状腺激素 甲状腺激素 甲状腺癌 甲状腺良性病变 

分 类 号：R446.61[医药卫生—诊断学]