直肠癌新辅助放化疗前后血清癌胚抗原与糖类抗原724的变化及临床意义  

The change and clinical significance of the serum levels of CEA and CA724 in patients with rectal cancer before and after neoadjuvant radiotherapy and chemotherapy

作　　者：杨平[1] 魏建昌[1] 张通[1] 陈华翠[1] 曾山崎[1] 曹杰[1] YANG Ping;WEI Jianchang;ZHANG Tong;CHEN Huacui;ZENG Shanqi;CAO Jie(Department of Gastrointestinal Surgery,Guangzhou First People′s Hospital,Guangzhou Medical University,Guangzhou,Guangdong 510180,China)

机构地区：[1]广州医科大学附属广州市第一人民医院胃肠外科,广州510180

出　　处：《国际检验医学杂志》2018年第4期400-402,407,共4页International Journal of Laboratory Medicine

基　　金：国家自然科学基金项目(81272556);广东省科技计划项目(2014A020212614);广州市科技计划项目(2014Y2-00137)

摘　　要：目的探讨直肠癌患者新辅助放化疗前后血清癌胚抗原(CEA)及糖类抗原724(CA724)水平的变化及临床意义。方法应用电化学发光法检测30例直肠癌患者(研究组)新辅助放化疗前后血清CEA与CA724的水平,并与30例健康人(对照组)作比较。结果研究组新辅助放化疗前血清CEA、CA724水平明显高于对照组,差异有统计学意义(P<0.05)。新辅助放化疗8周后,完全缓解组及部分缓解组化疗后CEA、CA724水平均较化疗前明显减低,差异有统计学意义(P<0.05),降低程度明显高于稳定组,差异有统计学意义(P<0.05);稳定组化疗后CEA、CA724较化疗前降低,差异有统计学意义(P<0.05);进展组化疗后CEA、CA724水平均较化疗前升高,差异有统计学意义(P<0.05);化疗前CEA、CA724水平呈正相关关系(r=0.862,P=0.000)。结论直肠癌患者血清中CEA、CA724均高表达,两者与直肠癌的发生、发展密切相关,测定直肠癌患者新辅助放化疗前后血清CEA、CA724水平的变化有助于临床判断新辅助放化疗疗效及肿瘤进程。Objective To explore the change and clinical significance of the serum carcinoembryonic antigen(CEA)and carbohydrate antigen 724(CA724)in patients with rectal cancer before and after neoadjuvant radiotherapy and chemotherapy.Methods The serum levels of CEA and CA724 of 30 patients with rectal carcinoma were detected by electrochemiluminescence method and were compared with those in 30 healthy people.Results The serum levels of CEA and CA724 in rectal carcinoma patients before neoadjuvant radiotherapy and chemotherapy were significantly higher than those in the healthy people,the difference was statistically significant(P<0.05).The serum levels in complete remission and partial remission patients after eight-week neoadjuvant radiotherapy and chemotherapy were significantly lower than those before treatment,the difference was statistically significant(P<0.05),and the reduction levels were obviously higher than those in the stable group,the difference was statistically significant(P<0.05).The CEA and CA724 levels in the stable treatment patients were also lower than those of before neoadjuvant radiotherapy and chemotherapy,the difference was statistically significant(P<0.05).The serum levels in the progression group were higher than those of before treatment(P<0.05).The serum levels of CEA and CA724 before neoadjuvant radiotherapy and chemotherapy existed a positive correlation(r=0.862,P=0.000).Conclusion The serum levels of CEA and CA724 in rectal cancer are highly expressed,suggesting that both of them are closely related to the occurrence and development of rectal carcinoma,the measurement of the serum level changes of CEA and CA724 in patients with rectal cancer before and after treatment contributes to estimate the efficacy of neoadjuvant radiotherapy and chemotherapy and tumor progression.

关 键 词：直肠癌 新辅助放化疗 癌胚抗原 糖类抗原724 

分 类 号：R446.62[医药卫生—诊断学] R735.37[医药卫生—临床医学]