血管性血友病因子在子痫前期发病机制中的研究进展  

Research progress of von Willebrand factor in the pathogenesis of pre-eclampsia

作　　者：陈晓娟 卢丹 蒋敏 Chen Xiaojuan;Lu Dan;Jiang Min(Dalian Medical University,Dalian 116044,Liaoning Province,China;Clinical Medicine School of Yangzhou University,Yangzhou 225009,Jiangsu Province,China)

机构地区：[1]大连医科大学,辽宁116044 [2]扬州大学临床医学院,江苏225009

出　　处：《中华妇幼临床医学杂志（电子版）》2018年第1期109-112,共4页Chinese Journal of Obstetrics & Gynecology and Pediatrics(Electronic Edition)

基　　金：江苏省妇幼健康科研项目(F201663);扬州市科技计划项目(YZ2017075)~~

摘　　要：子痫前期(PE)是妊娠期特发的高血压疾病,可伴有脑、心、肝、肾等多器官损害,是导致孕产妇及围生儿病死率和死亡率升高的主要原因。目前,PE的发病机制虽尚未完全阐明,但是临床一致认为,PE患者病情加重时必须及时终止妊娠。由此可见,了解PE的发病机制,早期预防和治疗PE具有重要的临床意义。血管性血友病因子(vWF)是内皮细胞损伤的重要标志物,文献报道,vWF与PE可能具有一定相关性。笔者拟就vWF在PE发病机制中的作用进行综述。Pre-eclampsia(PE)is an idiopathic hypertensive disease which frequently appear during pregnancy,and it is accompanied with multiple systemic damages such as brain,heart,liver,kidney,etc..PE is the main cause of the increase of maternal and perinatal morbidity and mortality.At present,the exploration of the specific pathogenesis of PE is still unclear,but it is certain that when PE continues to deteriorate,it can only be improved by terminating the pregnancy timely.So understanding the pathogenesis of PE,preventing and treating PE in early stage is of great significance.von willebrand factor(vWF)is an important marker of endothelial cell injury,while domestic and overseas studies have shown that vWF may associate with PE.This paper makes a review about the roles of vWF in the pathogenesis of PE.

关 键 词：von WILLEBRAND因子 先兆子痫 发病机制 血管内皮细胞损伤 孕妇 

分 类 号：R714.244[医药卫生—妇产科学]