藻蓝蛋白对氧化应激相关疾病防治作用的研究进展  

Research advances in the preventative and therapeutic effects of phycocyanin on oxidative stress-related diseases

作　　者：刘琪 李文军[2] 唐志红[3] 秦松[2] 杜振宁[1] LIU Qi;LI Wen-jun;TANG Zhi-hong;QIN Song;DU Zhen-ning(College of Pharmacy,Yantai University,Yantai 264005,China;Yantai Institute of Coastal Zone Research Chinese Academy of Sciences,Yantai 264003,China;College of life science,Yantai University,Yantai 264005,China)

机构地区：[1]烟台大学药学院,山东烟台264005 [2]中国科学院烟台海岸带研究所,山东烟台264003 [3]烟台大学生命科学学院,山东烟台264005

出　　处：《海洋科学》2017年第10期132-138,共7页Marine Sciences

基　　金：海洋公益性行业科研专项经费资助(201205027)~~

摘　　要：过去的40年,氧化应激在多种疾病的发生及恶化进程中的重要作用受到广泛关注。机体受到有害刺激后产生的氧化应激与动脉粥样硬化、肝炎、肺炎、阿尔兹海默病、白内障等多种疾病的发生有关,减轻氧化应激来防治以上疾病成为一种新思路。藻蓝蛋白作为从藻类中提取的天然产物,常被用作保健品及食品添加物,研究发现藻蓝蛋白可通过消除自由基、减轻氧化应激防治多种疾病。本文将藻蓝蛋白对氧化应激相关疾病的治疗或预防作用进行了综述,对其应用前景进行展望,为该活性蛋白的应用提供参考。Oxidative stress,which has attracted extensive research attention for over forty years,plays a crucial role in the occurrence and deterioration of various diseases.The oxidative stress resulting from harmful stimulation is related to many diseases,e.g.,atherosclerosis,hepatitis,pneumonia,Alzheimer’s disease,and cataracts.In this study,oxidative stress alleviation is presented in a new form to realize the prophylaxis and therapy of the above diseases.Phycocyanin,a natural product extracted from algae,is often used in health products and food additives.Research has found that phycocyanin has a beneficial effect in preventive treatments in different ways,such as the elimination of free radicals and reduction of oxidative stress.Here,we review the important role of phycocyanin in the prevention and cure of oxidative stress-related diseases and discuss the prospects for its application,which provide a reference for phycocyanin use in the future.

关 键 词：氧化应激 藻蓝蛋白 作用机制 

分 类 号：R963[医药卫生—微生物与生化药学]