磁共振扩散张量成像在大鼠C6脑胶质瘤分级中的应用研究  

Application of magnetic resonance diffusion tensor imaging in rat C6 glioma grading

作　　者：李香营[1] 蒋锡丽 杨光[1] 陈建强[1] 战跃福[1] 唐少虎[1] 韩向君[1] LI Xiangying;JIANG Xili;YANG Guang;CHEN Jianqiang;ZHAN Yuefu;TANG Shaohu;HAN Xiangjun(Department of Radiology,Affiliated Haikou Hospital,Xiangya School of Medicine,Central South University/ Haikou Municipal People′s Hospital,Haikou,Hainan 570208,China)

机构地区：[1]中南大学湘雅医学院附属海口医院/海口市人民医院放射科,海口570208

出　　处：《重庆医学》2018年第9期1153-1154,1157,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81360228);海南省自然科学基金资助项目(813259);海口市重点科技计划项目(2013-72;2011-0145);海南省卫生厅项目(琼卫2011-67)

摘　　要：目的探讨磁共振扩散张量成像(DTI)参数部分各向异性分数(FA)值在大鼠脑胶质瘤分级中的应用价值。方法67只雌性Wistar大鼠按照随机数字表法分成实验组57只,对照组10只,所有成活大鼠分别在接种后第1~2周(22只)和3~4周(35只)行3.0TDTI检查,获得瘤体FA值,并与病理结果对照。结果 57只荷瘤大鼠,其中低级别胶质瘤18只,高级别胶质瘤39只,DTI显示高级别胶质瘤瘤体FA值(0.167±0.035)高于低级别胶质瘤(0.147±0.015),差异有统计学意义(t=2.34,P<0.05)。结论 DTI参数FA值可以为术前胶质瘤分级提供准确可靠、无创的影像学信息。Objective To explore the application value of fractional anisotropy(FA)values of magnetic resonance diffusion tensor imaging(DTI)parameters in rat rat glioma grading.Methods Sixty-seven female Wistar rats were divided into the experimental group(n=57)and control group(n=10)according to the random number table method.All the surviving rats were examined by 3.0T DTI at 1-2 weeks(22 cases)and 3-4 weeks(35 cases)after inoculation,and the FA values of the tumor were obtained and compared with the pathological results.Results Among 57 tumor-loading rats,there were 18 low-grade gliomas and 39 high-grade gliomas.DTI showed that the FA value of high-grade gliomas was higher than that of the low-grade glioma,the difference was statistically significant[(0.167±0.035)vs.(0.147±0.015),t=2.34,P<0.05].Conclusion The FA value of DTI parameters can provide accurate,reliable and noninvasive imaging information for preoperative glioma grading.

关 键 词：胶质瘤 磁共振弥散张量成像 部分各向异性分数 大鼠 Wistar 

分 类 号：R445.2[医药卫生—影像医学与核医学]