火针治疗稳定期白癜风的临床疗效及其CLSM图像特点  

Clinical effect of fire needle in treating vitiligo and its CLSM image characteristics

作　　者：王禹毅[1] 刁庆春[1] 宁春竹 温馨[1] 余音[1] 徐伟[1] 陶春蓉[1] WANG Yuyi;DIAO Qingchun;NING Chunzhu;WEN Xin;YU Yin;XU Wei;TAO Chunrong(Department of Dermatology,Chongqing Municipal Hospital of Traditional Chinese Medicine/ Chongqing Municipal First People′s Hospital,Chongqing 400011,China)

机构地区：[1]重庆市中医院/重庆市第一人民医院皮肤科,400011

出　　处：《重庆医学》2018年第9期1155-1157,共3页Chongqing medicine

基　　金：国家自然科学基金资助项目(81503588);国家中医药重点学科专项经费资助(2209020301);重庆市卫生和计生委中医药科技项目(ZY20150237);重庆市基础与前沿研究计划项目(cstc2016jcyjAX0002);重庆市基础与前沿研究计划项目(cstc2015jcyjA10113);重庆市社会民生科技创新专项(cstc2016shms-zd10001-4)

摘　　要：目的评价火针治疗白癜风的临床疗效及皮肤激光扫描共聚焦显微镜(CLSM)图像特点。方法采用随机自身对照试验设计。每位患者选择2块对称或相邻白斑,随机接受火针治疗或他克莫司治疗,疗程为3个月。记录治疗前、火针治疗3次及6次后白斑CLSM图像。结果 41例白癜风稳定期患者,火针治疗组有效率为82.9%,他克莫司对照组有效率为78.0%,治疗后两组疗效比较差异无统计学意义(P>0.05)。火针治疗后,CLSM观察可见,树突状黑素细胞出现,基底层及真皮乳头周围逐步出现色素颗粒,形成色素环。结论火针和他克莫司治疗白癜风的疗效相当,且CLSM可作为白癜风黑素细胞恢复情况的无创性、客观可靠检测手段。Objective To evaluate the clinical effect of fire needle in treating vitiligo and the characteristics of vitiligo image by the confocal laser scanning microscope(CLSM).Methods The randomized self-controlled experiment design was adopted.Each patient selected two symmetric or adjacent white patches and randomly received the fire needle treatment or tacrolimus treatment.The duration of treatment was 3 months.The CLSM images of white patches were recorded before treatment and after 3,6 times of fire needle treatment.Results Among 41 cases of stable stage vitiligo,The effective rates of the fire needle group and tacrolimus group were 82.9%and 78.0%respectively,and the difference was not statistically significant(P>0.05).After fire needle treatment,dentritic melanin cells appeared,the pigment granules gradually appeared around the basal layer and corpora papillare,and formed the pigment ring.Conclusion Fire needle and tacrolimus have the similar effect in treating vitiligo,moreover CLSM can be used as the non-invasive,objective and reliable detection means of the recovery of vitiligo melanocyte.

关 键 词：火针 白癜风 皮肤共聚焦激光扫描显微镜 

分 类 号：R751.05[医药卫生—皮肤病学与性病学]