维生素D联合免疫球蛋白治疗小儿毛细支气管炎的疗效分析  

Efficacy of Vitamin D Combined with Immunoglobulin in the Treatment of Bronchiolitis in Children

作　　者：陈苹苹[1] 林利平[1] CHEN Ping-ping;LIN Li-ping(D epartm ent of Pediatrics,Jinjiang Hospital,Jinjiang,Fujian Province,362200 China)

机构地区：[1]福建省泉州市晋江市医院儿科,福建晋口362200

出　　处：《中外医疗》2017年第30期34-36,共3页China & Foreign Medical Treatment

摘　　要：目的探讨维生素D联合免疫球蛋白治疗小儿毛细支气管炎的临床疗效。方法该临床研究所选的小儿毛细支气管炎患儿的就诊时间为2016年5月—2017年5月,方便选取80例,按研究要求设置两组,即观察组(n=40)和对照组(n=40)。两组患儿均给予镇咳、平喘、祛痰、补液、氧疗、抗感染、抗病毒等常规治疗,观察组患儿额外给予维生素D联合免疫球蛋白进行治疗。结果观察组患儿哮鸣音消失时间、咳嗽缓解时间、喘息缓解时间、湿罗音消失时间分别为(2.59±1.04)、(6.73±1.06)、(4.74±1.01)、(5.12±1.05)d,均短于对照组的(3.27±1.12)、(8.57±1.38)、(6.20+1.16)、(6.39±1.21)d,组间比较差异有统计学意义(P<0.05)。观察组患儿治疗前的25羟维生素D3(25-(OH)D3)、免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)指标分别为(24.16±3.37)mmol/L、(0.21±0.06)g/L、(4.59±0.13)g/L,与对照组的(23.55±3.23)mmol/L、(0.22±0.04)g/L、(4.56±0.86)g/L均相当,组间比较差异无统计学意义(P>0.05);观察组患儿治疗后的25羟维生素D3(25-(OH)D3)、免疫球蛋白A(Ig A)、免疫球蛋白G(Ig G)指标分别为(76.53±7.69)mmol/L、(0.54±0.25)g/L、(6.50±1.36)g/L,均明显优于对照组的(26.54±3.65)mmol/L、(0.38±0.11)g/L、(5.18±1.22)g/L组间比较差异有统计学意义(P<0.05)。观察组患儿临床治疗总有效率为95.0%,高于对照组的62.5%,组间比较差异有统计学意义(P<0.05)。结论维生素D联合免疫球蛋白治疗小儿毛细支气管炎可有效缩短患儿的临床治疗起效时间、提高患儿的机体免疫功能,从而显著提高患儿的临床治疗效果。dex were(24.16±3.37)m m ol/L,(0.21±0.06)g/L,(4.59±0.13)g/L,sim ilar to the control group of(23.55±3.23)m m ol/L,(0.22土0.04)g/L and(4.56±0.86)g/L,the difference betw een groups was not sig n ifican t(P>0.0 5);the patients in the observation group after treatm ent of 25 hydroxyvitam in D3(25-(O H)D3),im m unoglobulin A(IgA),im m unoglobulin G(IgG)index were(76.53±7.69)mmol/L,(0.54+0.25)g/L,(6.50±1.36)g/L,significantly better than the control group of(26.54±3.65)m m ol/L,(0.38±0.11)g/L,(5.18±1.22)g/L,with significant differences(P<0.05).The total effective rate of clinical treatm ent in the observation group was 95.0%,higher than 62.5%in the control group,and there was a significant difference betw een the(P<0.05).Conclusion V itam in D com bined with im m unoglobulin in the treatm ent of children with bronchiolitis can effectively shorten the onset tim e,improve the im m une function of children,so as to improve the clinical effect of children.Objective This paper tries to investigate the clinical efficacy of vitam in D com bined with im m unoglobulin in the treatm ent of bronchiolitis in children.Methods 80 children with bronchiolitis from May 2016 to May 2017 were convenient selected and divided into two groups by the research requirem ents,the observation group(n=40)and control group(n=40).Two groups of children were given antitussive,antiasthm atic,expectorant,rehydration,oxygen therapy,anti-infection,an tiviral and other conventional treatm ent,the observation group was given additional vitam in D com bined with im m unoglobulin treatm ent.Results The observation group with w heeze disappeared tim e,rem ission tim e,cough asthm a rem ission time,rales disappearance time respectively were(2.59±1.04),(6.73±1.06),(4.74±1.01),(5.12±1.05)d,shorter than the control group of(3.27±1.12),(8.57±1.38),(6.20±1.16),and(6.39±1.21)d,with significant differences(P<0.05).The children in the observation group before treatm ent of 25 hydroxyvitamin D3(25-(O H)D3),im m unoglobulin A(IgA),im m unoglobulin G(IgG

关 键 词：维生素D 免疫球蛋白 小儿毛细支气管炎 

分 类 号：R725[医药卫生—儿科]