不同配比18α-与18β-甘草酸对酒精性肝损伤大鼠肝功能的影响  

The Effect of Different Proportion of 18α-,18β-Glycyrrhizic Acid on the Liver Function in Alcoholic Liver Disease Rat

作　　者：孙晓可 杨飒 孟祥波 周程艳 赵燕燕[1] SUN Xiaoke;YANG Sa;MENG Xiangbo;ZHOU Chengyan;ZHAO Yanyan(College of Pharmaceutical Science,Key Laboratory of Pharmaceutical Quality Control of Hebei Province, Hebei University,Baoding Hebei 071002,China)

机构地区：[1]河北大学药学院,河北省药物质量分析控制重点实验室,河北保定071002

出　　处：《江西师范大学学报（自然科学版）》2018年第2期166-170,共5页Journal of Jiangxi Normal University(Natural Science Edition)

基　　金：河北省自然科学基金(H2013201203)和河北大学医学学科专项资金(2014A1003)资助项目.

摘　　要：探讨不同配比18α-与18β-甘草酸(Gly)对大鼠酒精性肝损伤的影响.健康SD大鼠,雄性,随机分组,每组10只,即正常对照组(生理盐水)、模型对照组(生理盐水)、阳性药物对照组(水飞蓟宾)、7个给药组(18α-Gly与18β-Gly不同配比组,配比为10∶0,8∶2,6∶4,5∶5,4∶6,2∶8,0∶10).给药4周后,检测不同组对血清酶、血清蛋白、总胆红素、胆汁酸及血糖调控的影响.结果显示:18α-Gly与18β-Gly各个配比均能降低血清酶ALT、AST、γ-GT、LDH活性,随着18β-Gly比例增加作用增强,当18α-Gly与18β-Gly配比小于4∶6时,对缓解酒精性肝损伤和心肌损伤效果更佳;当配比大于8∶2时,对酒精性肝损伤大鼠血清蛋白水平的改善作用更加显著.当配比小于4∶6时,明显降低TBIL和TBA水平,显著改善酒精性肝损伤大鼠对血糖的调控能力.研究结果为新药研发和临床治疗的制剂选择提供依据.The objective is that investigating protective effects of different proportion of 18α-and 18β-glycyrrhizic acid(Gly)on alcoholic liver injury in rats.Healthy male rats are randomly divided into equally ten groups,respectively normal control group(saline),model group(saline),positive drug control group(silymarin),7 given drug groups(different ratios of 18α-Gly and 18β-Gly group,and ratios are 10∶0,8∶2,6∶4,5∶5,4∶6,2∶8,0∶10).At the fourth week,blood are collected to determine serum ferment and proteins,total bilirubin and acid bile.Blood glucose is measured.The results show that different proportions of 18α-and 18β-glycyrrhizic acid all effectively reduced ALT,AST,γ-GT and LDH activity.The alcoholic liver injury and myocardial injury can be better improved when the ratio is less than 4∶6.And the serum protein level in alcoholis liver injury rat is improved when the ratio is greater then 8∶2.The level of TBIL and TBA.And is attenuated when the ratio is less than 4∶6.And the proportion is less then 4∶6 that obviously improves the ability of regulating the blood glucose of rats with alcoholic liver injury.It can be applied to selection of new drug research and clinical treatment with a basic experiment data.

关 键 词：酒精性肝损伤 肝功能 不同配比 18α-甘草酸和18β-甘草酸 

分 类 号：R975.5[医药卫生—药品]