微卡联合化学药物治疗多耐药结核病临床疗效分析  

Clinical efficacy analysis of micro card combined with chemical drugs in the treatment of multi drug resistant tuberculosis

作　　者：毕占友[1] 郝军 陈忠建 刘占永 刘秀梅 Bi Zhanyou;Hao Jun;Chen Zhongjian(Langfang Center for Disease Control and Prevention,Langfang 065000)

机构地区：[1]河北省廊坊市疾病预防控制中心,廊坊065000 [2]河北省大城疾病预防控制中心,廊坊065900

出　　处：《陕西医学杂志》2018年第4期509-511,共3页Shaanxi Medical Journal

基　　金：河北省科技厅课题(5326861)

摘　　要：目的:探讨微卡联合化学药物治疗多耐药结核病的临床治疗效果。方法:选取收治的多耐药结核病患者80例,随机分为化学组和联合组,每组各40例,化学组单纯给予化学药物治疗,联合组在化学组的基础上联合微卡菌苗治疗,对比两组治疗后痰菌转阴、病灶闭合和免疫淋巴细胞群。结果:治疗后,联合组患者的痰菌转阴情况和病灶闭合情况优于化学组(P<0.05);联合组血清CD_4^+水平、CD_8^+水平及CD_4^+/CD_8^+水平均高于化学组(P<0.05)。结论:微卡联合化学药物治疗多耐药结核病的疗效确切,有效改善患者痰结核菌转阴,促进病灶愈合,提高患者的自身免疫力。Objective:To explore the clinical efficacy of micro card combined with chemical drugs in the treatment of multi drug resistant tuberculosis.Methods:80 patients with multi drug resistant tuberculosis I admitted to the unit were randomly divided into chemical group and combination group,40 cases in each group,chemical group received chemotherapy,combined group on the basis of chemical group combined with M.Vaccae treatment,compared two groups after the treatment,the sputum negative lesions closed lymphocyte subsets and immune.Results:After treatment,the sputum negative condition and lesion closure in the combined group were better than those in the chemical group(P<0.05);the serum CD 4+level,CD 8+level and CD 4+/CD 8+level in the combined group were higher than those in the chemical group(P<0.05).Conclusion:Micro card combined with chemical drugs in the treatment of multi drug resistant tuberculosis curative effect,effectively improve the sputum Mycobacterium tuberculosis negative,promote the healing of the lesion,improve the patient's own immunity.

关 键 词：广泛耐药结核 ＠微卡 ＠化学药物 

分 类 号：R521[医药卫生—内科学]