系统性红斑狼疮患者血清Hcy水平与病情严重程度相关性研究  

The correlation between serum Hcy level and severity of systemic lupus erythematosus

作　　者：吕静[1] 高洁[1] Lv Jing;Gao Jie(Department of Laboratory,Xi’an First Hospital Laboratory,Xi’an 710002)

机构地区：[1]西安市第一医院检验科,西安710002

出　　处：《陕西医学杂志》2018年第4期533-535,共3页Shaanxi Medical Journal

基　　金：国家自然科学基金资助重点项目(41271368)

摘　　要：目的:探讨系统性红斑狼疮(SLE)血清同型半胱氨酸(Hcy)水平与病情严重程度的相关性。方法:将系统性红斑狼疮患者71例作为研究对象,根据患者病情活动和骨骼有无坏死分为活动性SLE 34例和非活动性SLE 37例;选择同期入院进行体检的健康者36例作为对照组,检测三组患者血清Hcy水平,分析Hcy水平与SLE病情活动之间的关系。结果:SLE活动组的Hcy、TC、TG、LDL水平均明显高于SLE非活动组和对照组,HDL明显低于其余两组;SLE非活动组Hcy、TC、TG、LDL水平明显高于对照组,HDL明显低于对照组,组间比较差异具有统计学意义(P<0.05);SLE活动组患者SLEDAI评分明显高于SLE非活动组,组间比较差异具有统计学意义(P<0.05);血清Hcy和SLEDAI评分于SLE病情活动呈明显的正相关性(P<0.05),但其与TG、TC、LDL和HDL无明显的相关性(P>0.05)。结论:系统性红斑狼疮患者的血清Hcy水平明显高于正常人,高Hcy水平是SLE患者发生血管病变的一个独立危险因素,其水平和SLE病情活动程度呈正相关性,可作为临床评定SLE病情活动程度和治疗效果的指标。Objective:To investigate the relationship between serum Homocysteine(Hcy)level and severity of systemic lupus erythematosus(SLE).Methods:71 cases of systemic lupus erythematosus patients as the research object,according to the disease activity and bone necrosis were divided into 34 cases of active SLE and inactive SLE 37 cases were admitted during the same period;choose healthy 36 cases as control group.The three groups were detected the serum level of Hcy,analyze the relationship between Hcy level and the activity of SLE.Results:SLE activity group Hcy,TC,TG,LDL levels were significantly higher than those in non SLE group and control group,HDL was significantly lower than that of the other two groups;SLE group Hcy,TC,TG activities and LDL levels were higher than the control group,HDL was significantly lower than the control group,the difference was statistically significant(P<0.05);the SLE activity of patients with SLEDAI score was significantly higher than that in non SLE group,the difference was statistically significant(P<0.05);the serum Hcy and SLEDAI in SLE disease activity score was significantly positively correlated(P<0.05),however,serum Hcy and TG,TC,LDL and HDL no significant correlation(P>0.05).Conclusion:The serum Hcy level in patients with systemic lupus erythematosus was significantly higher than that of normal people,the high level of Hcy is an independent risk factor of vascular lesions in SLE patients,the level of SLE and the degree of disease activity was positively correlated,can be used as a clinical evaluation of SLE disease activity and degree of treatment effectiveness.

关 键 词：红斑狼疮 系统性 ＠同型半胱氨酸 对比研究 

分 类 号：R593.24[医药卫生—内科学]