尿毒清颗粒对解除梗阻后的梗阻性肾衰患者的疗效分析  

Effect of Niaoduqing Granules on Patients with Obstructive Renal Failure after Obstruction

作　　者：王胜 邓玮 黄子丹 WANG Sheng;DENG Wei;HUANG Zidan(Department of Urology,Guilin People's Hospital,Guilin Guangxi 541002,China)

机构地区：[1]桂林市人民医院泌尿外科,广西桂林541002 [2]梧州市人民医院泌尿外科

出　　处：《解放军预防医学杂志》2018年第2期214-216,223,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：广西壮族自治区科技厅支撑项目(No.201502057)

摘　　要：目的探讨梗阻性肾功能衰竭患者在解除梗阻后采用尿毒清颗粒进行治疗的临床价值。方法选取2015年1月-2017年1月于我院接受手术治疗的120例梗阻性肾衰患者,其中60例患者在解除梗阻后采用常规治疗+尿毒清治疗(研究组),另外60例患者给予常规治疗(对照组),对比两组患者治疗前和治疗2个月后的肾功能、微炎症指标以及临床效果。结果治疗前,研究组和对照组患者的肌酐(Scr)、尿素氮(BUN)、白蛋白(Alb)、前白蛋白(PAB)、内生肌酐清除率(CCR)比较,差异无统计学意义(P>0.05);治疗后,研究组的Scr、BUN水平显著低于对照组(P<0.05),研究组PAB、CCR水平显著高于对照组(P<0.05);治疗前,研究组和对照组患者的超敏C反应蛋白(hs-CRP)、白细胞介素-6(IL-6)、肿瘤坏死因子-ɑ(TNF-ɑ)水平差异无统计学意义(P>0.05);治疗后,研究组的hs-CRP、IL-6、TNF-ɑ水平显著低于对照组(P<0.05);治疗后,研究组的显效率为46.67%、有效率为50.00%、无效率为3.33%,对照组的显效率为28.33%、有效率为65.00%、无效率为6.67%,两组比较差异具有统计学意义(P<0.05)。结论梗阻性肾功能衰竭患者在解除梗阻后采用尿毒清颗粒进行治疗能促进患者肾功能恢复、降低微炎症反应状态,具有较好的临床治疗效果。Objective To explore the effect of Niaoduqing granules on patients with obstructive renal failure after obstruction.Methods A total of 120 patients with obstructive renal failure who had undergone surgical treatment in our hospital between January 2015 and January 2017 were selected.Sixty of them were treated with routine therapy and Niaoduqing granules after the obstruction was relieved(study group),while the other sixty patients were given routine treatment(control group).The renal function,index of micro-inflammation and clinical effect were compared between the two groups before treatment and 2 months after treatment.Results Before treatment,the levels of Scr,BUN,Alb,PAB and CCR in the study group and control group were not significantly different(P>0.05).After treatment,the levels of Scr and BUN in the study group were significantly lower than those in the control group(P<0.05).The levels of PAB and CCR in the study group were significantly higher than those in the control group(P<0.05).Before treatment,the levels of hs-CRP,IL-6 and TNF-αin the study group and the control group were not significantly different(P>0.05).After treatment,the levels of hs-CRP,IL-6 and TNF-αin the study group were significantly lower than those in the control group(P<0.05).After treatment,the highly effective rate was 46.67%,the effective rate was 50.00%,and the inefficiency rate was 3.33%in the study group,compared with 28.33%,65.00%and 6.67%in the control grop.There was significant difference between the two groups(P<0.05).Conclusion The use of Niaoduqing granules among patients with obstructive renal failure after obstruction can promote the recovery of renal function,reduce micro-inflammatory reactions,and produce good clinical effect.

关 键 词：梗阻 肾功能衰竭 尿毒清颗粒 

分 类 号：R692.5[医药卫生—泌尿科学]