臭氧对心血管系统影响的研究进展  

Research Progress in Effects of Ozone on Cardiovascular System

作　　者：杨虎 袭著革 刘晓华 初楠[1] YANG Hu;XI Zhuge;LIU Xiaohua;CHU Nan(The Affiliated Zhongshan Hospital of Dalian University,Dalian Liaoning 116001,China)

机构地区：[1]大连大学附属中山医院,辽宁大连116001 [2]军事科学院军事医学研究院环境医学与作业医学研究所

出　　处：《解放军预防医学杂志》2018年第2期271-274,共4页Journal of Preventive Medicine of Chinese People's Liberation Army

基　　金：“十三五”国家重点研发计划(No.2017YFC0211600)

摘　　要：目前我国大气污染问题严峻,近地面的空气污染物臭氧(O3)浓度不断升高,对人的潜在不利影响也越来越凸显。臭氧不仅对呼吸系统、神经系统和免疫系统的组织脏器有影响,对心血管系统也有较大的损伤。一系列的流行病学研究、志愿者实验和动物实验发现,臭氧对心血管系统造成危害的机制主要通过系统炎症、氧化应激、心肌细胞损伤、影响调节血管结构和转录机制、影响脂代谢、自主神经调节失衡等。本文对国内外有关臭氧对心血管系统的影响的文献报道做一简要综述。Current air pollution in China is heavy.The ozone(O3)concentration of the air near the ground is rising.The potential adverse impacts of O3 on humans are becoming increasingly prominent.Ozone not only affects the respiratory system,nervous system and immune system,but also takes a heavy toll on the cardiovascular system.A series of epidemiological studies,volunteer experiments and animal experiments have found that cardiovascular effects of O3 mainly work through systemic inflammation,oxidative stress,myocardial cell injury,regulation of vascular structure and transcription mechanism,lipid metabolism affection,and imbalance of autonomic nervous regulation.This article gives a brief overview of the literature on the effects of ozone on the cardiovascular system at home and abroad.

关 键 词：臭氧 心血管系统 系统炎症 氧化应激 脂代谢 死亡率 发病率 

分 类 号：R122.26[医药卫生—环境卫生学] X515[医药卫生—公共卫生与预防医学]