化学发光免疫分析法与酶联免疫吸附试验法对乙型肝炎病毒血清学标志物的对比研究  

Clinical comparison of ELISA and CLIA in the diagnosis of serologic markers for HBV patients

作　　者：蔡国平 CAI Guo-ping(The Second Affiliated Hospital Of Guangxi Medical University,Nanning,Guangxi,530007,China)

机构地区：[1]广西医科大学第二附属医院,广西南宁530007

出　　处：《蛇志》2018年第1期91-92,共2页Journal of Snake

摘　　要：目的探讨ELISA、CLIA对乙型肝炎病毒感染血清学标志物的临床检验价值。方法对我院2017年1~12月行乙肝病毒血清学检验的144例患者作为研究对象,将全部入选者随机分为研究组和对照组各72例,对照组采用ELISA检验法,研究组采用CLIA检验法,并对两组乙肝病毒血清学检验结果进行分析比较。结果研究组HBsAg、HBeAg、HBeAb等指标检出阳性率均明显高于对照组,差异有统计学意义(χ2=7.258,P=0.007;χ2=8.038,P=0.005;χ2=7.663,P=0.006)。结论相较于传统ELISA检验法,采用CLIA法行乙肝病毒血清学检验的结果更为准确,对早期明确诊断、防止疾病进展、改善患者预后等方面均具有积极意义,具有较高的临床应用价值。Objective To discuss the clinical value of ELISA and CLIA in the diagnosis of serologic markers for HBV(hepatitis B virus)patients. Methods 144 patients of receiving the examination of serologic markers from January 2017 to December 2017 in our hospital were selected.The subjects were randomly divided into two groups,72 cases each group.The control group adopted the ELISA method;the study group adopted the CLIA method.The serologic markers were examined. Results The positive detection rate of HBsAg,HBeAg and HBeAb for study group was significantly higher than control group(χ2=7.258,P=0.007;χ2=8.038,P=0.005;χ2=7.663,P=0.006). Conclusion Compared with the conventional ELISA method,the CLIA method has a better effect in the diagnosis of serologic markers,can improve the detection accuracy.It is of great importance to control the clinical progression of the disease and improve the clinical prognosis.

关 键 词：ELISA CLIA 乙型肝炎病毒感染 血清学标志物 阳性率 

分 类 号：R446.1[医药卫生—诊断学]