炎症因子在多囊卵巢综合征中作用的研究进展  

Research advances in the role of inflammatory factors in polycystic ovary syndrome

作　　者：刘兰心[1] 周承亮[2] 杨倩[1] 黄荷凤[1,2] LIU Lan-xin;ZHOU Cheng-liang;YANG Qian;HUANG He-feng(Institute of Embryonic Source Diseases,International Peace Maternity&Child Health Hospital,Shanghai Jiao Tong University School of Medicine,Shanghai 200030,China;Key Laboratory of Reproductive Genetics(Ministry of Education),Women's Hospital,Zhejiang University School of Medicine,Hangzhou 310058,China)

机构地区：[1]上海交通大学医学院附属国际和平妇幼保健院,胚胎源性疾病研究所,上海200030 [2]浙江大学医学院附属妇产科医院生殖遗传教育部重点实验室,杭州310058

出　　处：《上海交通大学学报（医学版）》2018年第3期328-332,共5页Journal of Shanghai Jiao tong University:Medical Science

基　　金：国家科技支撑计划(2012BAI32B00);国家自然科学基金(81450038)

摘　　要：多囊卵巢综合征(polycystic ovary syndrome,PCOS)是育龄期女性最常见的内分泌疾病,其主要特征包括稀发排卵或无排卵、卵巢多囊样表现以及高雄激素血症及其引起的痤疮、多毛等症状。目前认为PCOS患者的体内处于一个长期的慢性炎症过程,在外周血、颗粒细胞、卵泡液、卵巢组织、脂肪细胞和子宫内膜细胞中均发现炎症因子表达量的增高或炎症水平的升高。通过对炎症因子在PCOS发病中作用的研究,发现这些因子可能通过调控卵泡发育、雄激素水平等对临床结局产生影响。Polycystic ovary syndrome(PCOS)is the most common endocrine disorder affecting women of childbearing age,which features oligo-or anovulation,polycystic ovaries,hyperandrogenism and the related clinical signs,such as acne and hirsutism.At present,PCOS patients are considered to be in a long-time condition of chronic inflammation.It is reported that increased expression of inflammatory factors and/or increased levels of inflammation exist in peripheral blood,granulosa cells,follicular fluid,ovarian stroma,adipocytes and endometrial cells in patients with PCOS.Studies on the role of inflammatory factors in the pathogenesis of PCOS suggest that inflammatory factors may have an influence on the clinical outcome through affecting follicular development,androgen levels and so on.

关 键 词：多囊卵巢综合征 炎症 卵泡发育 雄激素 临床结局 

分 类 号：R588.6[医药卫生—内分泌]