孟鲁司特钠联合布地奈德对支气管哮喘患者肺功能、生活质量的影响  

Effect of montelukast combined with budesonide on lung function and quality of life in patients with bronchial asthma

作　　者：王静[1] 佟金平[1] 李剑[1] 姜秀秀 苗姝[1] WANG Jing;TONG Jin-ping;LI Jian(Department of Respiratory Medicine,Xinhua Hospital Affiliated to Dalian University,Dalian 116021,China)

机构地区：[1]大连大学附属新华医院呼吸内科,116021

出　　处：《中国现代药物应用》2018年第6期6-8,共3页Chinese Journal of Modern Drug Application

摘　　要：目的探讨孟鲁司特钠联合布地奈德对支气管哮喘患者肺功能、生活质量的影响。方法 64例支气管哮喘患者,随机分为联合组与对照组,各32例。对照组给予单纯布地奈德治疗,联合组在对照组基础上联合孟鲁司特钠治疗,对比两组治疗后咳嗽、睡眠、日间和夜间症状评分以及主要临床症状(咳嗽、喘憋、湿啰音及哮鸣音)消失时间,治疗前后肺功能指标[第一秒用力呼气容积/占用力肺活量百分比(FEV1/FVC)、最大呼气峰流速(PEF)]及生活质量改善情况。结果治疗后,联合组咳嗽、睡眠、日间及夜间症状评分均明显低于对照组,差异具有统计学意义(P<0.05)。联合组咳嗽、喘憋、湿啰音及哮鸣音主要临床症状消失时间均明显短于对照组,差异具有统计学意义(P<0.05)。治疗后,两组FEV1/FVC、PEF均明显高于治疗前,且联合组明显高于对照组,差异均具有统计学意义(P<0.05)。治疗后,两组生活质量评分明显高于治疗前,且联合组治疗后生活质量评分为(78.40±8.38)分,明显高于对照组的(67.36±7.53)分,差异具有统计学意义(P<0.05)。结论应用孟鲁司特钠联合布地奈德治疗支气管哮喘可显著改善患者临床症状、肺功能及生活质量,较单一用药疗效更加,值得推广。Objective To discuss the effect of montelukast combined with budesonide on lung function and quality of life in patients with bronchial asthma.Methods A total of 64 patients with bronchial asthma were randomly divided into combined group and control group,with 32 cases in each group.The control group was treated with budesonide,and the combined group was treated with montelukast on the basis of the control group.Comparison were made on cough,sleep,daytime and nighttime symptom scores and main clinical symptoms(cough,wheezing,rales and wheezes)disappearance time after treatment,and lung function indicators[first second forced expiratory volume/forced vital capacity percentage(FEV1/FVC),peak expiratory flow(PEF)]and quality of life improvement before and after treatment were recorded.Results After treatment,the combined group had obviously lower cough,sleep,daytime and nighttime symptom scores than the control group,and the difference was statistically significant(P<0.05).The combined group had obviously shorter main clinical symptom disappearance time of cough,wheezing,rales and wheezes than the control group,and the difference was statistically significant(P<0.05).After treatment,both groups had obviously higher FEV1/FVC and PEF than before treatment,and the combined group was obviously higher than the control group.Their difference was statistically significant(P<0.05).After treatment,both groups had obviously higher quality of life score than before treatment,and the combined group had obviously higher quality of life score after treatment as(78.40±8.38)points than(67.36±7.53)points in the control group.Their difference was statistically significant(P<0.05).Conclusion Application of montelukast and budesonide shows better efficacy than single medication in treating bronchial asthma,and it can significantly improve the clinical symptoms,lung function and quality of life.It is worthy of promotion.

关 键 词：孟鲁司特钠 布地奈德 支气管哮喘 肺功能 生活质量 

分 类 号：R562.25[医药卫生—呼吸系统]