SiO_2@Fe_3O_4复合纳米微球的合成及其对盐酸表柔比星的载药性能  

Synthesis of SiO_2@ Fe_3O_4 composite nanoparticles for the controlled release of epirubicin hydrochloride

作　　者：吴玲[1] 徐箐 李娣[2] 姜德立[2] 陈敏[2] WU Ling;XU Qing;LI Di;JIANG De-li;CHEN Min(Department of Clinical Laboratory, the Affiliated Hospital of Nanjing University of TCM, Nanjing Jiangsu 210029;School of Chemistry and Chemical Engineering, Jiangsu University, Zhenjiang Jiangsu 212013 , China)

机构地区：[1]南京中医药大学附属医院检验科,江苏南京210029 [2]江苏大学化学化工学院,江苏镇江212013

出　　处：《江苏大学学报（医学版）》2018年第2期169-173,共5页Journal of Jiangsu University：Medicine Edition

基　　金：镇江市工业支撑项目(GY2010020)

摘　　要：目的:制备新型磁性纳米微球SiO_2@Fe_3O_4,并考察其对盐酸表柔比星的载药性能。方法:以水热法制备的Fe_3O_4作为核,无水乙醇和水为共溶剂,一定浓度的氨水为催化剂,通过正硅酸四乙酯(tetraethyl orthosilicate,TEOS)的水解与缩合制备SiO_2@Fe_3O_4复合纳米微球,通过X射线衍射(XRD)法、透射电子显微镜(TEM)、红外吸收光谱(FT-IR)等测试样品的物相与结构,通过外加磁场测试其磁响应性,并通过药物吸附和缓释实验检测该纳米微球对表柔比星的载药性能。结果:当V(TEOS)=0.8 mL,V(氨水)=1.25 mL,V(水)∶V(无水乙醇)=1∶5时,SiO_2在Fe_3O_4微球表面包覆均匀完整,厚度约为60 nm。药物吸附实验显示,制备的SiO_2@Fe_3O_4复合纳米微球对表柔比星的吸附率为51.9%,磁响应性、体外稳定性和缓释效果均较好。结论:新型磁性纳米微球SiO_2@Fe_3O_4能有效吸附和缓释表柔比星,具有良好的磁响应性,可作为靶向纳米药物载体。Objective:To synthetize a new magnetic Si02@Fe304nanoparticles and evaluate the pe rformance of Si02@Fe304 for the epirubicin hydrochloride delive ry.Methods:Using the Fe304 nanoparticles prepared by hydrothermal method as the magnetic foundation,the magnetic Si02@Fe304 nanoparticles were prepared by hydrolysis and condensation of te traethyl orthosilicate(TEOS).The microstructure and properties of the samples were characterized by X-ray diffraction(XRD)method,transmission electron microscopy(TEM)and Fourier transform infrared spectroscopy(FT-IR).The magnetic responsiveness of S i02@Fe304nanoparticles was tested through magnetic field.The property of Si0 2@Fe304nanoparticles for the controlled release of epirubicin was eva luated.Results:The thickness of the Si02 layer was nearly 60 nm when V(te〇s)=0.8 mL,V(ammonia)=1.25 mL and V(water):V(alcohol)=1:5.The etrapment e fficiency of epirubicin hydrochloride was 51.9%and the products presented good dispersity and excellent stability.Conclusion:The magnetic Si02@Fe30 4nanoparticles could adsorb and delayedly release the epirubicin effectively.The Si02@Fe304nanocarriers displayed favorable magnetic responsiveness and have application prospects in the field of drug targeted nanocarriers.

关 键 词：盐酸表柔比星 S:i02@Fe30 4 靶向药物载体 

分 类 号：R979.1[医药卫生—药品]