音乐疗法对慢性应激性高血压大鼠的预防作用初探  

Preliminary study on the preventive effect of music therapy on chronic stress hypertension

作　　者：孙嘉绿 赵凡 乔田 郑焱江[2] 王玉芳[2] Sun Jia-lv;Zhao Fan;Qiao Tian;Zheng Yan-jiang;Wang Yu-fang(West China of Public Health,Sichuan University;West China School of basic Medical Sciences&Forensic Medicine,Sichuan University,Sichuan Chengdu 610041)

机构地区：[1]四川大学华西公共卫生学院 [2]四川大学华西基础医学与法医学院机能学实验室,四川成都610041

出　　处：《四川生理科学杂志》2018年第1期1-3,11,共4页Sichuan Journal of Physiological Sciences

基　　金：大学生创新创业训练计划省级项目(编号:201610610383)

摘　　要：目的:探讨音乐疗法对慢性应激性高血压的预防作用。方法:采用随机排列表法将24只雄性SD大鼠随机分为慢性应激组,慢性应激+音乐组(简称音乐组)和对照组。慢性应激组和音乐组接受28d足底电击结合噪声的复合刺激(上午8∶00~10∶00、下午2∶00~4∶00)以构建慢性应激性高血压大鼠模型,音乐组在接受慢性应激刺激的同时每日进行音乐干预(2h·d-1,65dB),此期间对照组大鼠正常饲养。实验结束后1w,采用尾压法测量大鼠的收缩压,酶联免疫法测量血清中的糖皮质激素含量。结果:实验后,慢性应激组大鼠收缩压明显高于音乐组(P<0.01)和对照组(P<0.01),音乐组血压略高于对照组,但差异无统计学意义(P>0.05)。酶联免疫法结果显示,慢性应激组大鼠血清糖皮质激素含量明显高于对照组(P<0.01)和音乐组(P<0.05),而音乐组和对照组大鼠血清中糖皮质激素含量差异无统计学意义(P>0.05)。结论:音乐疗法能有效预防慢性应激性高血压的发生。Objective:To explore the preventive effect of music therapy on chronic stress hypertension.Methods:Twenty-four male SD rats were divided into 3 groups equally by random number generator method:the chronic stress group,the chronic stress+music group(abbreviate for music group)and the control group.The rats in chronic stress group and the music group received 28 days of electric foot shock combined with noise to build chronic stress hypertension animal models(morning:8:00~10:00,afternoon:2:00~4:00),meanwhile with music intervention added to the music group(2 h·d-1,65 dB).During this period,the rats in control group were normally fed.One week after the experiment,tail pressure method and enzyme-linked immunosorbent assay(ELISA)were used to make comparisons of blood pressure and glucocorticoid in serum among them.Results:One week after the experiment,blood pressure of chronic stress group which was without music intervention was obviously higher than the music intervention group(P<0.01)and the control group(P<0.01),while the music intervention group was slightly higher than the control group(P>0.05).ELISA results showed that the serum concentration of glucocorticoid of chronic stress group was significantly higher than the control group(P<0.01)and the music intervention group(P<0.05),while the difference between the music intervention group and the control group was not statistically significant(P>0.05).Conclusion:Music therapy could effectively prevent chronic stress hypertension.

关 键 词：音乐疗法 慢性应激性高血压 糖皮质激素 大鼠 

分 类 号：R544.1[医药卫生—心血管疾病]