基于GC-MS方法的可卡因毒品中的杂质分析  

Analysis of Impurities in Seized Cocaine by GC/MS

作　　者：吴艳红 崔雪子 倪春芳[2] 吴忠平[2] 汪蓉[2] 梁晨[2] 张玉荣[2] WU Yan-hong;CUI Xue-zi;NI Chun-fang;WU Zhong-ping;WANG Rong;LIANG Chen;ZHANG Yu-rong(Shanghai Institute of Pharmaceutical Industry,China State Institute of Pharmaceutical Industry,State Key Laboratory of Innovative Pharmaceuticals and Pharmaceutical Industry,Shanghai 2O1203,China;Institute of Forensic Evidence,Shanghai Key Laboratory of Scene Evidence,Shanghai Municipal Public Security Bureau,Shanghai 2OOO83,China)

机构地区：[1]中国医药工业研究总院,上海医药工业研究院,创新药物与制药工艺国家重点实验室,上海201203 [2]上海市公安局物证鉴定中心上海市现场物证重点实验室,上海200083

出　　处：《中国司法鉴定》2018年第2期30-36,共7页Chinese Journal of Forensic Sciences

基　　金：上海市科委科研计划项目(16dz1205600)

摘　　要：目的通过GC-MS对49份可卡因检材进行杂质分析,对不同案件进行串并,推测可卡因生产路线。方法取10 mg可卡因检材溶解于1 m L甲醇中,2 u L进GC-MS分析。比较不同批次毒品间的杂质分布,推测各批次毒品生产路线并进行关联性分析。结果初步将49份可卡因检材分为7批,其中2批检材不含肉桂酰可卡因,推测经氧化过程处理提纯,与其余可卡因检材产地来源不同;其余5批检材均含肉桂酰可卡因,推测这5批基本产地来源一致,都采用重结晶提纯路线。结论本方法根据可卡因杂质信息进行案件的串并,初步推测所缴获可卡因毒品的生产路线。Object To classify and connect different cases through analyzing the impurities in seized cocaine by GC/MS,and to deduce the production routes.Method l0 mg of cocaine was dissolved in methanol,and 2 uL of the solution was analyzed by GC/MS.The distribution of impurities between batches of drugs were compared to deduce the production routes of different batches of drugs and analyze their relevance.Results The cocaine samples were initially divided into seven batches.Two batches don’t contain cinnamoylcocaine that were purified by oxidation process,indicating the different geographical origin from the rest of the drugs.Another five batches all contain cinnamoylcocaine that were purified by re-crystallization.Conclusion Based on the impurities in seized cocaine,this method successfully classified the cases,and provided the information of cocaine's production route.

关 键 词：可卡因 杂质分布 GC-MS 案件串并 生产路线 

分 类 号：DF795.4[医药卫生—法医学]