老年男性Ⅱ型糖尿病肾病患者骨密度测定及相关生化指标的分析  

Detection of bone mineral density and analysis of related biochemical indexes in elderly male patients with type 2 diabetic nephropathy

作　　者：冯云[1] 胡东[1] 朱昭环[1] 张德义[1] Feng Yun;Hu Dong;Zhu Zhaohuan;Zhang Deyi(Department of Radiology,First Hospital of Huaian Affiliated to Nanjing Medical University,Huaian 223300,China)

机构地区：[1]南京医科大学附属淮安第一医院放射科,江苏淮安223300

出　　处：《海军医学杂志》2018年第1期50-53,共4页Journal of Navy Medicine

摘　　要：目的探讨老年男性糖尿病肾病患者骨密度(bone mineral density,BMD)的改变及其与部分临床生化指标的联系。方法用双能X线骨密度仪测定129名糖尿病患者,其中正常蛋白尿组85例,微量蛋白尿组29例,大量蛋白尿组15例,正常对照组(HC)45例,分别测定各组正位腰椎(L2-4)、股骨颈(neck)、大转子区(torch)及ward三角区的BMD值,并收集部分临床和生化指标进行分析。结果 3组糖尿病患者股骨颈的T值分别为-1.06±1.07、-0.77±1.01、-2.18±1.01。大量蛋白尿组的BMD值显著低于其他各组,且骨质疏松发生率高于其他组,差异有统计学意义(P<0.05)。大量蛋白尿组的血钙浓度及血红蛋白值与HC组比,差异有统计学意义(P<0.05)。结论老年男性糖尿病肾病患者的BMD下降,骨质疏松的发生率增高,可能与血钙和糖化血红蛋白浓度的升高有关。To investigate changes of bone mineral density(BMD)in elderly men with diabetic nephropathy and its relationship with certain clinical biochemical indexes.Bone mineral density was detected with dual-energy X-ray absorptiometry in 129 patients with diabetes mellitus,including 85 in the normal albuminuria group,29 in the minute albuminuria group,15 in the mass albuminuria group and 45 in the normal control group.BMD levels of lumbar spine(L2-4),femoral neck,greater trochanter(torch)and the ward triangle were detected,and clinical and biochemical data were collected for further analysis.The carotid femoral T values in the patients of the 3 groups were respectively-1.06±1.07,-0.77±1.01 4 and-2.18±1.01.The BMD value in the mass albuminuria group was significantly lower than that in the other groups,and the incidence of osteoporosis was higher than that of the other groups,and statistical significance could be noted when comparisons were made between them(P<0.05).As compared with those of the normal control group,the levels of serum calcium and hemoglobin in the mass albuminuria group were significantly lower,also with statistical significance(P<0.05).Bone mineral density n those elderly male patients with diabetic nephropathy decreased obviously and the incidence of osteoporosis also increased,which might be associated with the increase of serum calcium and HbA1c.

关 键 词：糖尿病肾病 老年男性 骨质疏松 双能X线 

分 类 号：R587.2[医药卫生—内分泌]