乌司他丁对肺外源ARDS患者肺毛细血管通透性及呼吸功能的影响分析  被引量:2

Effect of ulinastatin on pulmonary capillary permeability and respiratory function in patients with lung exogenous ARDS

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作  者:匡智明 刘丽珍 Kuang Zhiming;Liu Lizhen(Department of Severe Medicine,Ganzhou People's Hospital,Ganzhou,Jiangxi,341000,China;Department of Functional Medicine,Ganzhou Maternal and Child Health Hospital,Ganzhou,Jiangxi,341000,China)

机构地区:[1]赣州市人民医院重症医学科,江西赣州341000 [2]赣州市妇幼保健院功能科,江西赣州341000

出  处:《当代医学》2018年第10期3-5,共3页Contemporary Medicine

摘  要:目的研究乌司他丁用于肺外源ARDS(急性呼吸窘迫综合征)治疗中对于患者肺毛细血管通透性和呼吸功能的影响。方法选取2015年1月~2017年6月赣州市人民医院综合ICU就诊的肺外源ARDS患者中选出90例,随机分成两组,每组45例。对照组患者给予常规对症治疗,观察组患者在对照组的基础上加用乌司他丁治疗,对比两组患者的肺毛细血管通透性指数等。结果经过3 d的治疗,两组患者的PVPI指数、EVLWI指数、氧合指数以及呼吸频率均有明显的改善(P<0.05);其中各个指标改善程度上观察组患者均高于对照组(P<0.05);同时在机械通气时间和ICU入住时间上,观察组患者短于对照组患者(P<0.05)。结论乌司他丁与常规对症疗法配合用于肺外源ARDS治疗中效果确切,有助于促进患者肺毛细血管通透性降低和呼吸功能改善,值得推广。Objective To study the effects of ulinastatin on pulmonary capillary permeability and respiratory function in patients with pulmonary exogenous ARDS(acute respiratory distress syndrome)treatment.Methods 90 cases selected from the Ganzhou People's Hospital from January 2015 to June 2017 from ICU lung exogenous ARDS patients,were randomly divided into two groups,the control group were given routine symptomatic treatment,the patients in the observation group were added with ulinastatin treatment on the basis of the control group,compared two groups of patients with pulmonary vascular permeability index.Results After 3 days treatment,the two groups of patients with PVPI index,EVLWI index,oxygenation index and respiratory rate were improved significantly(P<0.05);the various indicators of the degree of improvement on the patients in the observation group were higher than those in control group(P<0.05);at the same time,mechanical ventilation time and ICU stay time,patients in the observation group shorter than the control group(P<0.05).Conclusion Ulinastatin combined with conventional symptomatic therapy is effective in the treatment of pulmonary foreign ARDS,and is helpful to promote the decrease of pulmonary capillary permeability and respiratory function,and is worthy of promotion.

关 键 词:乌司他丁 肺外源ARDS 肺毛细血管通透性 呼吸功能 

分 类 号:R563.8[医药卫生—呼吸系统]

 

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