口炎清颗粒对大鼠阴虚火旺型口腔溃疡的改善作用  

Protective effects of Kouyanqing Granule on the oral ulcer rat model with Yin-xu-huo-wang syndrome

作　　者：刘宏[1] 郑艳芳[1] 李楚源[2] 王德勤[2] 彭维[1] 姚宏亮[1] 苏薇薇[1] LIU Hong;ZHENG Yanfang;LI Chuyuan;WANG Deqin;PENG Wei;YAO Hongliang;SU Weiwei(School of Life Sciences,Sun Yat-sen University,Guangzhou 510275,China;Hutchison Whampoa Guangzhou Baiyunshan Chinese Medicine Company Limited,Guangzhou 510515,China)

机构地区：[1]中山大学生命科学学院,广东广州510275 [2]广州白云山和记黄埔中药有限公司,广东广州510515

出　　处：《中山大学学报（自然科学版）》2018年第2期131-136,共6页Acta Scientiarum Naturalium Universitatis Sunyatseni

基　　金：中山大学成果转化项目(33000-18825004);广州市民生科技攻关计划课题(201803010082)

摘　　要：口炎清颗粒是治疗口腔炎症的名优中成药,具有滋阴清热、解毒消肿的功效。基于中医理论的病证结合思想,通过注射三碘甲状腺原氨酸并结合苯酚灼烧刺激,建立阴虚火旺型口腔溃疡动物模型;在此基础上,通过生化指标检测、病理组织观察,研究口炎清颗粒在减少组织损伤、促进溃疡愈合方面的改善作用;对指导其临床用药提供了依据。Kouyanqing Granule(KYQG)is a famous Chinese herbal formula for the treatment of oral diseases in clinic.Based on the Disease-syndrome theory of traditional Chinese medicine,the present study established an oral ulcer rat model with Yin-xu-huo-wang syndrome by the combination of 3,3′,5-triiodothyronine injection and phenol burning.Through this rat model,KYQG s protective effects on reducing oral damage and promoting ulcer healing were evaluated including parameter detection and histopathological observation.

关 键 词：口炎清颗粒 阴虚火旺 口腔溃疡 动物模型 药效作用 

分 类 号：R965[医药卫生—药理学]