安徽省滁州地区2016年细菌耐药性监测  

Surveillance of bacterial resistance in hospitals across Anhui Chuzhou in 2016

作　　者：徐添天 谢强[1] 曹明杰[1] 谢瑞玉[1] 陈玲[1] 张友祥 李祥[3] 诸波[3] 陈园园 李海燕 赵广海 XU Tiantian;XIE Qiang;CAO Mingjie;XIE Ruiyu;CHEN Ling;ZHANG Youxiang;LI Xiang;ZHU Bo;CHEN Yuanyuan;LI Haiyan;ZHAO Guanghai(Department of Laboratory Medicine,Chuzhou First Hospital,Chuzhou Anhui 239001,China)

机构地区：[1]滁州市第一人民医院检验科,安徽滁州239001 [2]滁州市第二人民医院 [3]滁州市中西医结合医院 [4]皖东人民医院 [5]滁州市第五人民医院 [6]定远县总医院

出　　处：《中国感染与化疗杂志》2018年第2期195-200,共6页Chinese Journal of Infection and Chemotherapy

摘　　要：目的了解2016年安徽省滁州地区细菌耐药性监测结果。方法采用纸片扩散法(K-B法)对滁州地区6所医院所分离菌株进行药敏试验,按CLSI 2015版标准判断结果,采用WHONET5.6进行耐药性分析。结果 2016年共收集临床分离菌5 465株,其中革兰阳性菌1 416株,占25.9%;革兰阴性菌4 049株,占74.1%。葡萄球菌属中耐甲氧西林金黄色葡萄球菌(MRSA)和耐甲氧西林凝固酶阴性葡萄球菌(MRCNS)分别占各自菌种的37.6%和78.1%。葡萄球菌属及肠球菌属中未见万古霉素和利奈唑胺耐药株。大肠埃希菌、克雷伯菌属(肺炎克雷伯菌和产酸克雷伯菌)和奇异变形杆菌超广谱β内酰胺酶(ESBL)的检出率分别为51.2%、23.4%和23.6%。肠杆菌科细菌对美罗培南和亚胺培南较敏感。铜绿假单胞菌对所检测的抗菌药物耐药率均低于30%。不动杆菌属对美罗培南和亚胺培南的耐药率分别为65.6%和67.4%。结论细菌的耐药性日趋严重,多重耐药和泛耐药菌株应引起高度重视。Objective To investigate the bacterial resistance profile of clinical isolates collected in the hospitals across Chuzhou in 2016.Methods Antimicrobial susceptibility testing was carried out by Kirby-Bauer method.The data were analyzed using WHONET 5.6 software according to CLSI 2015 breakpoints.Results A total of 5 465 clinical isolates were collected during 2016,of which gram positive organisms and gram negative organisms accounted for 25.9%(1 416/5 465)and 74.1%(4 049/5 465),respectively.Prevalence of MRSA was 37.6%among S.aureus and the prevalence of MRCNS was 78.1%in CNS.All Staphylococcus,E.faecalis and E.faecium isolates were sensitive to vancomycin and linezolid.The prevalence of extended spectrum-lactamases(ESBLs)positive strains was 51.2%in E.coli,23.4%in Klebsiella spp.(K.pneumoniae and K.oxytoca),and 23.6%in P.mirabilis isolates,respectively.The Enterobacteriaceae strains were highly sensitive to carbapenems.The percentage of the P.aeruginosa isolates resistant to the antimicrobials tested was lower than 30%.The percentage of the Acinetobacter strains resistant to meropenem and imipenem was 65.6%and 67.4%,respectively.Conclusions The situation of antibiotic resistance is still very serious,especially multi-drug or pan-drug resistant strains,which is of great concern.

关 键 词：耐药性监测 多重耐药 泛耐药 

分 类 号：R378[医药卫生—病原生物学]