血尿酸水平与糖尿病周围神经病变相关性研究  

Correlation between Serum Uric Acid Level and Diabetic Peripheral Neuropathy

作　　者：蒋凤秀[1] 陆泽元[1] 曾玲[1] 余颖 张华清 庄雄杰 JIANG Fengxiu;LU Ze-yuan;ZENG Ling;YU Yin;ZHANG Hua-qing;ZHUANG Xiong-jie(Department of Endocrinology,the Eighth Affiliated Hospital of Sun Yatsen University;Department of Endocrinology,Xili People’s Hospital of Nanshan District of Shenzhen,Shenzhen 518033,China)

机构地区：[1]中山大学附属第八医院内分泌科 [2]深圳市南山区西丽人民医院内分泌科,广东深圳518033

出　　处：《实用临床医学（江西）》2018年第1期1-4,共4页Practical Clinical Medicine

基　　金：深圳市福田区卫生公益性科研项目(FTWS20160015)

摘　　要：目的探讨血尿酸(SUA)水平与糖尿病周围神经病变(DPN)的关系。方法以448例2型糖尿病(T2DM)患者为研究对象(男289例,女159例),根据SUA四分位法对患者进行分组,其中男性:Q1组(SUA<290μmol·L-1)、Q2组(290μmol·L-1≤SUA<345μmol·L-1)、Q3组(345μmol·L-1≤SUA<404μmol·L-1)、Q4组(SUA≥404μmol·L-1);女性:Q1组(SUA<262μmol·L-1)、Q2组(262μmol·L-1≤SUA<319μmol·L-1)、Q3组(319μmol·L-1≤SUA<374μmol·L-1)、Q4组(SUA≥374μmol·L-1)。结果 448例患者中DPN患病率为38.6%(男38.4%,女39.0%)。男性Q1、Q2、Q3、Q4组DPN患病率分别为23.6%、38.9%、41.7%、49.3%(P<0.01);女性Q1、Q2、Q3、Q4组DPN患病率为23.1%、27.5%、47.5%、57.5%(P<0.01)。Logistics回归分析校正空腹血糖、糖尿病病程、年龄、糖化血红蛋白(HbA1c)、血压、血脂、eGFR、尿微量白蛋白/尿肌酐比值(UACR)、高血压患病率、口服他汀类降脂药、口服降压药物等混杂因素后,证实SUA与DPN独立相关。以Q1组发生DPN为1,男性Q2、Q3、Q4组风险比分别为:2.43(1.14~5.16)、2.76(1.30~5.87)、3.54(1.66~7.53)(P<0.01);女性Q2、Q3、Q4组风险比分别为:2.43(1.14~5.16)、2.76(1.30~5.87)、3.54(1.66~7.53)(P<0.01)。结论随着SUA水平的升高,DPN患病率升高。Objective To investigate the relationship between serum uric acid(SUA)level and diabetic peripheral neuropathy(DPN).Methods A total of 289 male patients and 159 female patients with type 2 diabetes mellitus(T2DM)were respectively divided into four groups.males:Q1(SUA<290μmol·L-1),Q2(290μmol·L-1≤SUA<345μmol·L-1),Q3(345μmol·L-1≤SUA<404μmol·L-1),Q4(SUA≥404μmol·L-1);females:Q1(SUA<262μmol·L-1),Q2(262μmol·L-1≤SUA<319μmol·L-1),Q3(319μmol·L-1≤SUA<374μmol·L-1),Q4(SUA≥374μmol·L-1).Results The overall prevalence rate of DPN was 38.6%in the 448 patients(38.4%in males and 39.0%in females).The prevalence rates of DPN in Q1,Q2,Q3 and Q4 groups were respectively 23.6%,38.9%,41.7%and 49.3%in males(P<0.01),and 23.1%,27.5%,47.5%and 57.5%in females(P<0.01).After correction for fasting blood glucose,diabetes duration,age,glycosylated hemogloglobin,blood pressure,blood lipid,estimated glomerular filtration rate,urine albumin\|to\|creatinine ratio,hypertension prevalence,lipid\|lowering therapy with oral statins,oral antihypertensive treatment and other confounding factors by logistic regression analysis,a relationship was confirmed between SUA and DPN.When DPN in group Q1 was set to 1,the risk ratios in Q2,Q3 and Q4 groups were respectively 2.43(1.14\|5.16),2.76(1.30\|5.87)and 3.54(1.66\|7.53)in males(P<0.01),and 2.43(1.14\|5.16),2.76(1.30\|5.87)and 3.54(1.66\|7.53)in females(P<0.01).Conclusion The incidence of DPN increases with the rise in SUA level.

关 键 词：糖尿病周围神经病变 2型糖尿病 血尿酸 

分 类 号：R587.2[医药卫生—内分泌]