血浆脑利钠肽在小儿川崎病中的变化及其与心功能的相关性分析  

Analysis of the Changes of Plasma Brain Natriuretic Peptide in children with Kawasaki Disease and its Correlation with Heart Function

作　　者：石正英[1] 管建宏 胡静 SHI Zhengying;GUAN Jianhong;HU Jing(The People's Hospital of Rugao,Jiangsu Rugao 226500,China)

机构地区：[1]江苏省如皋市人民医院儿科,江苏如皋226500 [2]江苏省无锡市儿童医院心内科,江苏无锡214023

出　　处：《河北医学》2018年第3期430-433,共4页Hebei Medicine

基　　金：江苏省无锡市科技计划项目;(编号:CSZ00905)

摘　　要：目的:探讨血浆脑利钠肽在小儿川崎病中的变化及其与心功能的相关性。方法:将2015年7月至2017年7月我院收治的川崎病患儿39例作为观察组,根据病情分为急性期患儿20例,恢复期患儿19例;另将同期在我院进行健康体检的儿童50例作为对照组,检测两组血浆脑利钠肽水平,同时检测观察组各项心功能指标,分析患儿血浆脑利钠肽水平与心功能相关性。结果:急性期患儿血浆脑利钠肽水平明显高于恢复期和对照组,差异有统计学意义(P<0.05);恢复期患儿血浆脑利钠肽水平高于对照组,差异有统计学意义(P<0.05);急性期患儿LVSF、CI、LVEF指标明显低于恢复期,差异有统计学意义(P<0.05);急性期患儿E/A指标与恢复期比较,差异无统计学意义(P>0.05);血浆脑利钠肽水平与急性期患儿LVSF、CI、LVEF指标呈现明显负相关(P<0.05),与E/A指标无明显相关性(P>0.05)。结论:川崎病急性期患儿血浆脑利钠肽水平明显上升,与LVSF、CI、LVEF呈负相关,对于患儿临床早期诊断至关重要。Objective:To investigate the changes of plasma brain natriuretic peptide in children with Kawasaki disease and its correlation with cardiac function.Methods:From July 2015 to July 2017 in our hospital,39 cases of pediatric children with Kawasaki disease as the observation group,according to the disease is divided into 20 cases of acute children,19 cases of convalescent patients;the same period in our hospital 50 cases of healthy children as a control group.The levels of plasma brain natriuretic peptide were detected in the two groups.Meanwhile,the cardiac function indexes in the observation group were also examined.The correlation between plasma brain natriuretic peptide and cardiac function was analyzed.Results:The levels of plasma brain natriuretic peptide in acute stage were significantly higher than those in recovery stage and control group(P<0.05).The level of plasma natriuretic peptide in convalescent group was higher than that in control group,the difference was statistically significant(P<0.05).The indexes of LVSF,CI,LVEF in acute stage were significantly lower than those in recovery stage,the difference was statistically significant(P<0.05).The difference of E/A index and recovery period There was no significant difference between the two groups(P>0.05).Sodium levels of plasma brain natriuretic peptide and children with acute LVSF,CI,LVEF indicators show a significant negative correlation(P<0.05),and E/A showed no significant correlation(P>0.05).Conclusion:The level of plasma brain natriuretic peptide in children with acute Kawasaki disease is significantly increased,which is negatively correlated with LVSF,CI and LVEF,which is of great importance for early clinical diagnosis in children.

关 键 词：血浆脑利钠肽 小儿 川崎病 心功能 

分 类 号：R725.4[医药卫生—儿科]